Magnetic Particle Imaging: In vitro Signal Analysis and Lumen Quantification of 21 Endovascular Stents

Franz Wegner,1,* Anselm von Gladiss,2,* Julian Haegele,1,3 Ulrike Grzyska,1 Malte Maria Sieren,1 Erik Stahlberg,1 Thekla Helene Oechtering,1 Kerstin Lüdtke-Buzug,2 Joerg Barkhausen,1 Thorsten M Buzug,2,4 Thomas Friedrich2,4 1Department of Radiology and Nuclear Medicine, University of L&...

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Autores principales:	Wegner F, von Gladiss A, Haegele J, Grzyska U, Sieren MM, Stahlberg E, Oechtering TH, Lüdtke-Buzug K, Barkhausen J, Buzug TM, Friedrich T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	magnetic particle imaging endovascular stents artifacts superparamagnetic iron oxide nanoparticles lumen quantification Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d6a582a9ba6b425483fc11ebbfd7ad6a
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spelling	oai:doaj.org-article:d6a582a9ba6b425483fc11ebbfd7ad6a2021-12-02T13:36:08ZMagnetic Particle Imaging: In vitro Signal Analysis and Lumen Quantification of 21 Endovascular Stents1178-2013https://doaj.org/article/d6a582a9ba6b425483fc11ebbfd7ad6a2021-01-01T00:00:00Zhttps://www.dovepress.com/magnetic-particle-imaging-in-vitro-signal-analysis-and-lumen-quantific-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Franz Wegner,1,* Anselm von Gladiss,2,* Julian Haegele,1,3 Ulrike Grzyska,1 Malte Maria Sieren,1 Erik Stahlberg,1 Thekla Helene Oechtering,1 Kerstin Lüdtke-Buzug,2 Joerg Barkhausen,1 Thorsten M Buzug,2,4 Thomas Friedrich2,4 1Department of Radiology and Nuclear Medicine, University of Lübeck, Lübeck, Germany; 2Institute of Medical Engineering, University of Lübeck, Lübeck, Germany; 3Zentrum für Radiologie und Nuklearmedizin Rheinland, Dormagen, Germany; 4Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering, Lübeck, Germany*These authors contributed equally to this workCorrespondence: Franz WegnerUniversity Hospital Schleswig-Holstein, Campus Lübeck, Department of Radiology and Nuclear Medicine, Ratzeburger Allee 160, Lübeck 23538, GermanyTel +004945150017001Fax +004945150017004Email franz.wegner@uksh.dePurpose: Endovascular stents are medical devices, which are implanted in stenosed blood vessels to ensure sufficient blood flow. Due to a high rate of in-stent re-stenoses, there is the need of a noninvasive imaging method for the early detection of stent occlusion. The evaluation of the stent lumen with computed tomography (CT) and magnetic resonance imaging (MRI) is limited by material-induced artifacts. The purpose of this work is to investigate the potential of the tracer-based modality magnetic particle imaging (MPI) for stent lumen visualization and quantification.Methods: In this in vitro study, 21 endovascular stents were investigated in a preclinical MPI scanner. Therefore, the stents were implanted in vessel phantoms. For the signal analysis, the phantoms were scanned without tracer material, and the signal-to-noise-ratio was analyzed. For the evaluation of potential artifacts and the lumen quantification, the phantoms were filled with diluted tracer agent. To calculate the stent lumen diameter a calibrated threshold value was applied.Results: We can show that it is possible to visualize the lumen of a variety of endovascular stents without material induced artifacts, as the stents do not generate sufficient signals in MPI. The stent lumen quantification showed a direct correlation between the calculated and nominal diameter (r = 0.98).Conclusion: In contrast to MRI and CT, MPI is able to visualize and quantify stent lumina very accurately.Keywords: magnetic particle imaging, endovascular stents, artifacts, superparamagnetic iron oxide nanoparticles, lumen quantificationWegner Fvon Gladiss AHaegele JGrzyska USieren MMStahlberg EOechtering THLüdtke-Buzug KBarkhausen JBuzug TMFriedrich TDove Medical Pressarticlemagnetic particle imagingendovascular stentsartifactssuperparamagnetic iron oxide nanoparticleslumen quantificationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 213-221 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetic particle imaging endovascular stents artifacts superparamagnetic iron oxide nanoparticles lumen quantification Medicine (General) R5-920
spellingShingle	magnetic particle imaging endovascular stents artifacts superparamagnetic iron oxide nanoparticles lumen quantification Medicine (General) R5-920 Wegner F von Gladiss A Haegele J Grzyska U Sieren MM Stahlberg E Oechtering TH Lüdtke-Buzug K Barkhausen J Buzug TM Friedrich T Magnetic Particle Imaging: In vitro Signal Analysis and Lumen Quantification of 21 Endovascular Stents
description	Franz Wegner,1,* Anselm von Gladiss,2,* Julian Haegele,1,3 Ulrike Grzyska,1 Malte Maria Sieren,1 Erik Stahlberg,1 Thekla Helene Oechtering,1 Kerstin Lüdtke-Buzug,2 Joerg Barkhausen,1 Thorsten M Buzug,2,4 Thomas Friedrich2,4 1Department of Radiology and Nuclear Medicine, University of Lübeck, Lübeck, Germany; 2Institute of Medical Engineering, University of Lübeck, Lübeck, Germany; 3Zentrum für Radiologie und Nuklearmedizin Rheinland, Dormagen, Germany; 4Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering, Lübeck, Germany*These authors contributed equally to this workCorrespondence: Franz WegnerUniversity Hospital Schleswig-Holstein, Campus Lübeck, Department of Radiology and Nuclear Medicine, Ratzeburger Allee 160, Lübeck 23538, GermanyTel +004945150017001Fax +004945150017004Email franz.wegner@uksh.dePurpose: Endovascular stents are medical devices, which are implanted in stenosed blood vessels to ensure sufficient blood flow. Due to a high rate of in-stent re-stenoses, there is the need of a noninvasive imaging method for the early detection of stent occlusion. The evaluation of the stent lumen with computed tomography (CT) and magnetic resonance imaging (MRI) is limited by material-induced artifacts. The purpose of this work is to investigate the potential of the tracer-based modality magnetic particle imaging (MPI) for stent lumen visualization and quantification.Methods: In this in vitro study, 21 endovascular stents were investigated in a preclinical MPI scanner. Therefore, the stents were implanted in vessel phantoms. For the signal analysis, the phantoms were scanned without tracer material, and the signal-to-noise-ratio was analyzed. For the evaluation of potential artifacts and the lumen quantification, the phantoms were filled with diluted tracer agent. To calculate the stent lumen diameter a calibrated threshold value was applied.Results: We can show that it is possible to visualize the lumen of a variety of endovascular stents without material induced artifacts, as the stents do not generate sufficient signals in MPI. The stent lumen quantification showed a direct correlation between the calculated and nominal diameter (r = 0.98).Conclusion: In contrast to MRI and CT, MPI is able to visualize and quantify stent lumina very accurately.Keywords: magnetic particle imaging, endovascular stents, artifacts, superparamagnetic iron oxide nanoparticles, lumen quantification
format	article
author	Wegner F von Gladiss A Haegele J Grzyska U Sieren MM Stahlberg E Oechtering TH Lüdtke-Buzug K Barkhausen J Buzug TM Friedrich T
author_facet	Wegner F von Gladiss A Haegele J Grzyska U Sieren MM Stahlberg E Oechtering TH Lüdtke-Buzug K Barkhausen J Buzug TM Friedrich T
author_sort	Wegner F
title	Magnetic Particle Imaging: In vitro Signal Analysis and Lumen Quantification of 21 Endovascular Stents
title_short	Magnetic Particle Imaging: In vitro Signal Analysis and Lumen Quantification of 21 Endovascular Stents
title_full	Magnetic Particle Imaging: In vitro Signal Analysis and Lumen Quantification of 21 Endovascular Stents
title_fullStr	Magnetic Particle Imaging: In vitro Signal Analysis and Lumen Quantification of 21 Endovascular Stents
title_full_unstemmed	Magnetic Particle Imaging: In vitro Signal Analysis and Lumen Quantification of 21 Endovascular Stents
title_sort	magnetic particle imaging: in vitro signal analysis and lumen quantification of 21 endovascular stents
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/d6a582a9ba6b425483fc11ebbfd7ad6a
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Magnetic Particle Imaging: In vitro Signal Analysis and Lumen Quantification of 21 Endovascular Stents

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