Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis

Osteoarthritis (OA) is associated with cartilage degeneration, and no effective therapy exists. Here, the authors show that the HPIP protein modulates OA progression by regulating Wnt signaling, and that its knockdown in joints via AAV-mediated gene silencing attentuates pathology.

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Autores principales:	Quanbo Ji, Xiaojie Xu, Lei Kang, Yameng Xu, Jingbo Xiao, Stuart B. Goodman, Xiang Zhu, Wenchao Li, Juan Liu, Xu Gao, Zhifeng Yan, Yuxuan Zheng, Zheng Wang, William J. Maloney, Qinong Ye, Yan Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d6a96617087f4e3a820a0eb31eac902e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:d6a96617087f4e3a820a0eb31eac902e2021-12-02T14:35:37ZHematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis10.1038/s41467-018-08277-52041-1723https://doaj.org/article/d6a96617087f4e3a820a0eb31eac902e2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08277-5https://doaj.org/toc/2041-1723Osteoarthritis (OA) is associated with cartilage degeneration, and no effective therapy exists. Here, the authors show that the HPIP protein modulates OA progression by regulating Wnt signaling, and that its knockdown in joints via AAV-mediated gene silencing attentuates pathology.Quanbo JiXiaojie XuLei KangYameng XuJingbo XiaoStuart B. GoodmanXiang ZhuWenchao LiJuan LiuXu GaoZhifeng YanYuxuan ZhengZheng WangWilliam J. MaloneyQinong YeYan WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Quanbo Ji Xiaojie Xu Lei Kang Yameng Xu Jingbo Xiao Stuart B. Goodman Xiang Zhu Wenchao Li Juan Liu Xu Gao Zhifeng Yan Yuxuan Zheng Zheng Wang William J. Maloney Qinong Ye Yan Wang Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis
description	Osteoarthritis (OA) is associated with cartilage degeneration, and no effective therapy exists. Here, the authors show that the HPIP protein modulates OA progression by regulating Wnt signaling, and that its knockdown in joints via AAV-mediated gene silencing attentuates pathology.
format	article
author	Quanbo Ji Xiaojie Xu Lei Kang Yameng Xu Jingbo Xiao Stuart B. Goodman Xiang Zhu Wenchao Li Juan Liu Xu Gao Zhifeng Yan Yuxuan Zheng Zheng Wang William J. Maloney Qinong Ye Yan Wang
author_facet	Quanbo Ji Xiaojie Xu Lei Kang Yameng Xu Jingbo Xiao Stuart B. Goodman Xiang Zhu Wenchao Li Juan Liu Xu Gao Zhifeng Yan Yuxuan Zheng Zheng Wang William J. Maloney Qinong Ye Yan Wang
author_sort	Quanbo Ji
title	Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis
title_short	Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis
title_full	Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis
title_fullStr	Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis
title_full_unstemmed	Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis
title_sort	hematopoietic pbx-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d6a96617087f4e3a820a0eb31eac902e
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Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis

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