Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction

Abstract Preeclampsia (PE) and fetal growth restriction (FGR) are both placenta-mediated disorders with unclear pathogenesis. Metabolomics of maternal and fetal pairs might help in understanding these disorders. We recruited prospectively pregnancies with normotensive FGR, PE without FGR, PE + FGR a...

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Autores principales:	Lina Youssef, Rui V. Simões, Jezid Miranda, María Luisa García-Martín, Cristina Paules, Francesca Crovetto, Nuria Amigó, Nicolau Cañellas, Eduard Gratacos, Fatima Crispi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d6aaaf41e16a4bf398e8f7ed65b26696
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spelling	oai:doaj.org-article:d6aaaf41e16a4bf398e8f7ed65b266962021-12-02T18:30:39ZPaired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction10.1038/s41598-021-93936-92045-2322https://doaj.org/article/d6aaaf41e16a4bf398e8f7ed65b266962021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93936-9https://doaj.org/toc/2045-2322Abstract Preeclampsia (PE) and fetal growth restriction (FGR) are both placenta-mediated disorders with unclear pathogenesis. Metabolomics of maternal and fetal pairs might help in understanding these disorders. We recruited prospectively pregnancies with normotensive FGR, PE without FGR, PE + FGR and uncomplicated pregnancies as controls. Nuclear magnetic resonance metabolomics were applied on plasma samples collected at delivery. Advanced lipoprotein, glycoprotein and choline profiling was performed using the Liposcale test. The software package Dolphin was used to quantify 24 low-molecular-weight metabolites. Statistical analysis comprised the comparison between each group of complicated pregnancies versus controls, considering 5% false discovery rate correction. Lipid profiles were altered in accordance with the clinical presentation of these disorders. Specifically, PE mothers and FGR fetuses (with or without FGR or PE, respectively) exhibited a pro-atherogenic and pro-inflammatory profile, with higher concentrations of triglycerides, remnant cholesterol (VLDL, IDL) and Glc/GalNAc-linked and lipid-associated glycoproteins compared to controls. Low-molecular-weight metabolites were extensively disturbed in preeclamptic mothers, with or without FGR. Growth restricted fetuses in the presence of PE showed changes in low-molecular-weight metabolites similar to their mothers (increased creatine and creatinine), while normotensive FGR fetuses presented scarce differences, consistent with undernutrition (lower isoleucine). Further research is warranted to clarify maternal and fetal adaptations to PE and FGR.Lina YoussefRui V. SimõesJezid MirandaMaría Luisa García-MartínCristina PaulesFrancesca CrovettoNuria AmigóNicolau CañellasEduard GratacosFatima CrispiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lina Youssef Rui V. Simões Jezid Miranda María Luisa García-Martín Cristina Paules Francesca Crovetto Nuria Amigó Nicolau Cañellas Eduard Gratacos Fatima Crispi Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction
description	Abstract Preeclampsia (PE) and fetal growth restriction (FGR) are both placenta-mediated disorders with unclear pathogenesis. Metabolomics of maternal and fetal pairs might help in understanding these disorders. We recruited prospectively pregnancies with normotensive FGR, PE without FGR, PE + FGR and uncomplicated pregnancies as controls. Nuclear magnetic resonance metabolomics were applied on plasma samples collected at delivery. Advanced lipoprotein, glycoprotein and choline profiling was performed using the Liposcale test. The software package Dolphin was used to quantify 24 low-molecular-weight metabolites. Statistical analysis comprised the comparison between each group of complicated pregnancies versus controls, considering 5% false discovery rate correction. Lipid profiles were altered in accordance with the clinical presentation of these disorders. Specifically, PE mothers and FGR fetuses (with or without FGR or PE, respectively) exhibited a pro-atherogenic and pro-inflammatory profile, with higher concentrations of triglycerides, remnant cholesterol (VLDL, IDL) and Glc/GalNAc-linked and lipid-associated glycoproteins compared to controls. Low-molecular-weight metabolites were extensively disturbed in preeclamptic mothers, with or without FGR. Growth restricted fetuses in the presence of PE showed changes in low-molecular-weight metabolites similar to their mothers (increased creatine and creatinine), while normotensive FGR fetuses presented scarce differences, consistent with undernutrition (lower isoleucine). Further research is warranted to clarify maternal and fetal adaptations to PE and FGR.
format	article
author	Lina Youssef Rui V. Simões Jezid Miranda María Luisa García-Martín Cristina Paules Francesca Crovetto Nuria Amigó Nicolau Cañellas Eduard Gratacos Fatima Crispi
author_facet	Lina Youssef Rui V. Simões Jezid Miranda María Luisa García-Martín Cristina Paules Francesca Crovetto Nuria Amigó Nicolau Cañellas Eduard Gratacos Fatima Crispi
author_sort	Lina Youssef
title	Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction
title_short	Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction
title_full	Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction
title_fullStr	Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction
title_full_unstemmed	Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction
title_sort	paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d6aaaf41e16a4bf398e8f7ed65b26696
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Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction

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