Myogenin promotes myocyte fusion to balance fibre number and size

Loss of the transcription factor Myogenin in mice reduces skeletal myogenesis and leads to perinatal death but how Myogenin regulates muscle formation is unclear. Here, the authors show that zebrafish Myogenin enhances Myomaker expression, muscle cell fusion and myotome size, yet decreases fast musc...

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Autores principales:	Massimo Ganassi, Sara Badodi, Huascar Pedro Ortuste Quiroga, Peter S. Zammit, Yaniv Hinits, Simon M. Hughes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d6aaafc55e244efe901b9d6408377f25
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spelling	oai:doaj.org-article:d6aaafc55e244efe901b9d6408377f252021-12-02T15:34:46ZMyogenin promotes myocyte fusion to balance fibre number and size10.1038/s41467-018-06583-62041-1723https://doaj.org/article/d6aaafc55e244efe901b9d6408377f252018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06583-6https://doaj.org/toc/2041-1723Loss of the transcription factor Myogenin in mice reduces skeletal myogenesis and leads to perinatal death but how Myogenin regulates muscle formation is unclear. Here, the authors show that zebrafish Myogenin enhances Myomaker expression, muscle cell fusion and myotome size, yet decreases fast muscle fibre number.Massimo GanassiSara BadodiHuascar Pedro Ortuste QuirogaPeter S. ZammitYaniv HinitsSimon M. HughesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Massimo Ganassi Sara Badodi Huascar Pedro Ortuste Quiroga Peter S. Zammit Yaniv Hinits Simon M. Hughes Myogenin promotes myocyte fusion to balance fibre number and size
description	Loss of the transcription factor Myogenin in mice reduces skeletal myogenesis and leads to perinatal death but how Myogenin regulates muscle formation is unclear. Here, the authors show that zebrafish Myogenin enhances Myomaker expression, muscle cell fusion and myotome size, yet decreases fast muscle fibre number.
format	article
author	Massimo Ganassi Sara Badodi Huascar Pedro Ortuste Quiroga Peter S. Zammit Yaniv Hinits Simon M. Hughes
author_facet	Massimo Ganassi Sara Badodi Huascar Pedro Ortuste Quiroga Peter S. Zammit Yaniv Hinits Simon M. Hughes
author_sort	Massimo Ganassi
title	Myogenin promotes myocyte fusion to balance fibre number and size
title_short	Myogenin promotes myocyte fusion to balance fibre number and size
title_full	Myogenin promotes myocyte fusion to balance fibre number and size
title_fullStr	Myogenin promotes myocyte fusion to balance fibre number and size
title_full_unstemmed	Myogenin promotes myocyte fusion to balance fibre number and size
title_sort	myogenin promotes myocyte fusion to balance fibre number and size
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d6aaafc55e244efe901b9d6408377f25
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Myogenin promotes myocyte fusion to balance fibre number and size

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