Application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges

Muhammad Zaman,1 Sundus Qureshi,1 Kishwar Sultana,1 Muhammad Hanif,2 Asif Mahmood,1 Zaib Ali Shaheryar,1 Faisal Gulzar,1 Kashif Barkat,1 Mohamed M Abdel-Daim3 1Faculty of Pharmacy, University of Lahore, Lahore, Pakistan; 2Department of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan; 3Dep...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zaman M, Qureshi S, Sultana K, Hanif M, Mahmood A, Shaharyar ZA, Gulzar F, Barkat K, Abdel-Daim MM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Tacrolimus Microsponges Quasi- emulsification XRD and FTIR Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d6ad1c1805304742a6b61fe3698607e1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d6ad1c1805304742a6b61fe3698607e1
record_format	dspace
spelling	oai:doaj.org-article:d6ad1c1805304742a6b61fe3698607e12021-12-02T03:38:32ZApplication of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges1178-2013https://doaj.org/article/d6ad1c1805304742a6b61fe3698607e12018-08-01T00:00:00Zhttps://www.dovepress.com/application-of-quasi-emulsification-and-modified-double-emulsification-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Muhammad Zaman,1 Sundus Qureshi,1 Kishwar Sultana,1 Muhammad Hanif,2 Asif Mahmood,1 Zaib Ali Shaheryar,1 Faisal Gulzar,1 Kashif Barkat,1 Mohamed M Abdel-Daim3 1Faculty of Pharmacy, University of Lahore, Lahore, Pakistan; 2Department of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan; 3Department of Pharmacology, Suez Canal University, Ismailia, Egypt Background: The present study was to develop a stable and sustained-release delivery system of tacrolimus (TCM). TCM is a macrolide antibiotic used as an immunosuppressant. It is formulated as a microsponge, which is a safe and effective delivery system with reduced side effects.Materials and methods: The method used to prepare ethyl cellulose (EC) and xanthan gum (XG)-facilitated EC-based microsponges employed emulsification and modified double emulsification techniques. TCM-containing microsponges were prepared using varying concentrations followed by evaluation of micromeritics, compatibility of drug and excipients, production yield, drug content and entrapment efficiency, zeta potential, size distribution and drug release.Results: The results showed excellent flow properties with adequate entrapment efficiency of the system and satisfactory release of active pharmaceutical ingredient. In vitro dissolution studies, which were conducted to determine the amount of drug released, illustrated a pronounced sustained effect up to 8 h. Zeta size and zeta potential analysis of microsponges confirmed the existence of micro-sized (1.99–3.09 µm) and stable particles (-15.33 to -3.38 mV), respectively.Conclusion: Conclusively, the applied technique and selected combination of ingredients were found suitable for the preparation of TCM-containing sustained-release microsponges. Keywords: ethylcellulose, xanthan gum, macrolides, tacrolimus, sustained releaseZaman MQureshi SSultana KHanif MMahmood AShaharyar ZAGulzar FBarkat KAbdel-Daim MMDove Medical PressarticleTacrolimusMicrospongesQuasi- emulsificationXRD and FTIRMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 4537-4548 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Tacrolimus Microsponges Quasi- emulsification XRD and FTIR Medicine (General) R5-920
spellingShingle	Tacrolimus Microsponges Quasi- emulsification XRD and FTIR Medicine (General) R5-920 Zaman M Qureshi S Sultana K Hanif M Mahmood A Shaharyar ZA Gulzar F Barkat K Abdel-Daim MM Application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges
description	Muhammad Zaman,1 Sundus Qureshi,1 Kishwar Sultana,1 Muhammad Hanif,2 Asif Mahmood,1 Zaib Ali Shaheryar,1 Faisal Gulzar,1 Kashif Barkat,1 Mohamed M Abdel-Daim3 1Faculty of Pharmacy, University of Lahore, Lahore, Pakistan; 2Department of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan; 3Department of Pharmacology, Suez Canal University, Ismailia, Egypt Background: The present study was to develop a stable and sustained-release delivery system of tacrolimus (TCM). TCM is a macrolide antibiotic used as an immunosuppressant. It is formulated as a microsponge, which is a safe and effective delivery system with reduced side effects.Materials and methods: The method used to prepare ethyl cellulose (EC) and xanthan gum (XG)-facilitated EC-based microsponges employed emulsification and modified double emulsification techniques. TCM-containing microsponges were prepared using varying concentrations followed by evaluation of micromeritics, compatibility of drug and excipients, production yield, drug content and entrapment efficiency, zeta potential, size distribution and drug release.Results: The results showed excellent flow properties with adequate entrapment efficiency of the system and satisfactory release of active pharmaceutical ingredient. In vitro dissolution studies, which were conducted to determine the amount of drug released, illustrated a pronounced sustained effect up to 8 h. Zeta size and zeta potential analysis of microsponges confirmed the existence of micro-sized (1.99–3.09 µm) and stable particles (-15.33 to -3.38 mV), respectively.Conclusion: Conclusively, the applied technique and selected combination of ingredients were found suitable for the preparation of TCM-containing sustained-release microsponges. Keywords: ethylcellulose, xanthan gum, macrolides, tacrolimus, sustained release
format	article
author	Zaman M Qureshi S Sultana K Hanif M Mahmood A Shaharyar ZA Gulzar F Barkat K Abdel-Daim MM
author_facet	Zaman M Qureshi S Sultana K Hanif M Mahmood A Shaharyar ZA Gulzar F Barkat K Abdel-Daim MM
author_sort	Zaman M
title	Application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges
title_short	Application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges
title_full	Application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges
title_fullStr	Application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges
title_full_unstemmed	Application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges
title_sort	application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/d6ad1c1805304742a6b61fe3698607e1
work_keys_str_mv	AT zamanm applicationofquasiemulsificationandmodifieddoubleemulsificationtechniquesforformulationoftacrolimusmicrosponges AT qureshis applicationofquasiemulsificationandmodifieddoubleemulsificationtechniquesforformulationoftacrolimusmicrosponges AT sultanak applicationofquasiemulsificationandmodifieddoubleemulsificationtechniquesforformulationoftacrolimusmicrosponges AT hanifm applicationofquasiemulsificationandmodifieddoubleemulsificationtechniquesforformulationoftacrolimusmicrosponges AT mahmooda applicationofquasiemulsificationandmodifieddoubleemulsificationtechniquesforformulationoftacrolimusmicrosponges AT shaharyarza applicationofquasiemulsificationandmodifieddoubleemulsificationtechniquesforformulationoftacrolimusmicrosponges AT gulzarf applicationofquasiemulsificationandmodifieddoubleemulsificationtechniquesforformulationoftacrolimusmicrosponges AT barkatk applicationofquasiemulsificationandmodifieddoubleemulsificationtechniquesforformulationoftacrolimusmicrosponges AT abdeldaimmm applicationofquasiemulsificationandmodifieddoubleemulsificationtechniquesforformulationoftacrolimusmicrosponges
_version_	1718401702517800960

Application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges

Ejemplares similares