Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses

Traditional herbal medicines, which emphasize a holistic, patient-centric view of disease treatment, provide an exciting starting point for discovery of new immunomodulatory drugs. Progress on identification of herbal molecules with proven single agent activity has been slow, in part because of insu...

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Autores principales:	Jue Shi, Jui-Hsia Weng, Timothy J Mitchison
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	immunomodulatory drug xenobiotic defense drug discovery plant-derived molecules traditional chinese medicine organ-specific drug action Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d6b0a2b6a13946478001a3f73cb6437e
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spelling	oai:doaj.org-article:d6b0a2b6a13946478001a3f73cb6437e2021-11-15T10:12:47ZImmunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses10.7554/eLife.736732050-084Xe73673https://doaj.org/article/d6b0a2b6a13946478001a3f73cb6437e2021-11-01T00:00:00Zhttps://elifesciences.org/articles/73673https://doaj.org/toc/2050-084XTraditional herbal medicines, which emphasize a holistic, patient-centric view of disease treatment, provide an exciting starting point for discovery of new immunomodulatory drugs. Progress on identification of herbal molecules with proven single agent activity has been slow, in part because of insufficient consideration of pharmacology fundamentals. Many molecules derived from medicinal plants exhibit low oral bioavailability and rapid clearance, leading to low systemic exposure. Recent research suggests that such molecules can act locally in the gut or liver to activate xenobiotic defense pathways that trigger beneficial systemic effects on the immune system. We discuss this hypothesis in the context of four plant-derived molecules with immunomodulatory activity: indigo, polysaccharides, colchicine, and ginsenosides. We end by proposing research strategies for identification of novel immunomodulatory drugs from herbal medicine sources that are informed by the possibility of local action in the gut or liver, leading to generation of systemic immune mediators.Jue ShiJui-Hsia WengTimothy J MitchisoneLife Sciences Publications Ltdarticleimmunomodulatory drugxenobiotic defensedrug discoveryplant-derived moleculestraditional chinese medicineorgan-specific drug actionMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunomodulatory drug xenobiotic defense drug discovery plant-derived molecules traditional chinese medicine organ-specific drug action Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	immunomodulatory drug xenobiotic defense drug discovery plant-derived molecules traditional chinese medicine organ-specific drug action Medicine R Science Q Biology (General) QH301-705.5 Jue Shi Jui-Hsia Weng Timothy J Mitchison Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses
description	Traditional herbal medicines, which emphasize a holistic, patient-centric view of disease treatment, provide an exciting starting point for discovery of new immunomodulatory drugs. Progress on identification of herbal molecules with proven single agent activity has been slow, in part because of insufficient consideration of pharmacology fundamentals. Many molecules derived from medicinal plants exhibit low oral bioavailability and rapid clearance, leading to low systemic exposure. Recent research suggests that such molecules can act locally in the gut or liver to activate xenobiotic defense pathways that trigger beneficial systemic effects on the immune system. We discuss this hypothesis in the context of four plant-derived molecules with immunomodulatory activity: indigo, polysaccharides, colchicine, and ginsenosides. We end by proposing research strategies for identification of novel immunomodulatory drugs from herbal medicine sources that are informed by the possibility of local action in the gut or liver, leading to generation of systemic immune mediators.
format	article
author	Jue Shi Jui-Hsia Weng Timothy J Mitchison
author_facet	Jue Shi Jui-Hsia Weng Timothy J Mitchison
author_sort	Jue Shi
title	Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses
title_short	Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses
title_full	Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses
title_fullStr	Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses
title_full_unstemmed	Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses
title_sort	immunomodulatory drug discovery from herbal medicines: insights from organ-specific activity and xenobiotic defenses
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/d6b0a2b6a13946478001a3f73cb6437e
work_keys_str_mv	AT jueshi immunomodulatorydrugdiscoveryfromherbalmedicinesinsightsfromorganspecificactivityandxenobioticdefenses AT juihsiaweng immunomodulatorydrugdiscoveryfromherbalmedicinesinsightsfromorganspecificactivityandxenobioticdefenses AT timothyjmitchison immunomodulatorydrugdiscoveryfromherbalmedicinesinsightsfromorganspecificactivityandxenobioticdefenses
_version_	1718428463775350784

Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses

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