Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells

The Mll3/4 histone methyltransferases can act as tumour suppressors in humans. Here, the authors identify three orthologs of mammalian MLL3/4 in the planarian Schmidtea mediterranea and show that knockdown causes outgrowths in regenerating animals, suggesting that the tumour suppressive function of...

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Autores principales:	Yuliana Mihaylova, Prasad Abnave, Damian Kao, Samantha Hughes, Alvina Lai, Farah Jaber-Hijazi, Nobuyoshi Kosaka, A. Aziz Aboobaker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d6b21974aa2f41b0889a0c888a7d36c3
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spelling	oai:doaj.org-article:d6b21974aa2f41b0889a0c888a7d36c32021-12-02T17:31:58ZConservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells10.1038/s41467-018-06092-62041-1723https://doaj.org/article/d6b21974aa2f41b0889a0c888a7d36c32018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06092-6https://doaj.org/toc/2041-1723The Mll3/4 histone methyltransferases can act as tumour suppressors in humans. Here, the authors identify three orthologs of mammalian MLL3/4 in the planarian Schmidtea mediterranea and show that knockdown causes outgrowths in regenerating animals, suggesting that the tumour suppressive function of these genes is deeply conserved.Yuliana MihaylovaPrasad AbnaveDamian KaoSamantha HughesAlvina LaiFarah Jaber-HijaziNobuyoshi KosakaA. Aziz AboobakerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuliana Mihaylova Prasad Abnave Damian Kao Samantha Hughes Alvina Lai Farah Jaber-Hijazi Nobuyoshi Kosaka A. Aziz Aboobaker Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells
description	The Mll3/4 histone methyltransferases can act as tumour suppressors in humans. Here, the authors identify three orthologs of mammalian MLL3/4 in the planarian Schmidtea mediterranea and show that knockdown causes outgrowths in regenerating animals, suggesting that the tumour suppressive function of these genes is deeply conserved.
format	article
author	Yuliana Mihaylova Prasad Abnave Damian Kao Samantha Hughes Alvina Lai Farah Jaber-Hijazi Nobuyoshi Kosaka A. Aziz Aboobaker
author_facet	Yuliana Mihaylova Prasad Abnave Damian Kao Samantha Hughes Alvina Lai Farah Jaber-Hijazi Nobuyoshi Kosaka A. Aziz Aboobaker
author_sort	Yuliana Mihaylova
title	Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells
title_short	Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells
title_full	Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells
title_fullStr	Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells
title_full_unstemmed	Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells
title_sort	conservation of epigenetic regulation by the mll3/4 tumour suppressor in planarian pluripotent stem cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d6b21974aa2f41b0889a0c888a7d36c3
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Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells

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