Role of surfactant proteins in viral keratitis

Innate immunity plays an important role in viral keratitis. Recently, it has been found that surfactant proteins(SP)A and D in the innate immune system are essential in viral keratitis. SP can inhibit virus adhesion to host cells and further promote phagocytosis of virus through high affinity for vi...

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Autores principales:	Qi Wan, Zhi-Yong Zhang, Shuo Yang
Formato:	article
Lenguaje:	EN
Publicado:	Press of International Journal of Ophthalmology (IJO PRESS) 2021
Materias:	surfactant protein d surfactant protein a viral infection viral keratitis antiviral effect Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/d6b24f489f5e40ecb232c87cf430fa78
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spelling	oai:doaj.org-article:d6b24f489f5e40ecb232c87cf430fa782021-11-22T14:22:32ZRole of surfactant proteins in viral keratitis1672-512310.3980/j.issn.1672-5123.2021.12.09https://doaj.org/article/d6b24f489f5e40ecb232c87cf430fa782021-12-01T00:00:00Zhttp://ies.ijo.cn/cn_publish/2021/12/202112009.pdfhttps://doaj.org/toc/1672-5123Innate immunity plays an important role in viral keratitis. Recently, it has been found that surfactant proteins(SP)A and D in the innate immune system are essential in viral keratitis. SP can inhibit virus adhesion to host cells and further promote phagocytosis of virus through high affinity for virus ligands. In order to ensure the normal function of tissues in the early stage of virus infection, SP regulates immune cells to maintain a non-inflammatory state. However, when pathogen invasion increases, SP promoted inflammation and increased the immune cells to kill the pathogens. SP-A and SP-D could be expressed in cornea, conjunctiva. To play the role of anti-adenovirus, herpes simplex virus, cytomegalovirus and other major eye pathogenic viruses, SP-A and SP-D combine with the virus to prevent entry into cells, promote phagocytosis, and directly kill the virus. SP-A and SP-D may be used as clinical diagnostic tools for viral infection. In the future, recombinant SP is expected to be used as an important means for the treatment of viral keratitis. Here, we review the innate immune function of SP-A and SP-D in ocular viral infection.Qi WanZhi-Yong ZhangShuo YangPress of International Journal of Ophthalmology (IJO PRESS)articlesurfactant protein dsurfactant protein aviral infectionviral keratitisantiviral effectOphthalmologyRE1-994ENGuoji Yanke Zazhi, Vol 21, Iss 12, Pp 2072-2075 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	surfactant protein d surfactant protein a viral infection viral keratitis antiviral effect Ophthalmology RE1-994
spellingShingle	surfactant protein d surfactant protein a viral infection viral keratitis antiviral effect Ophthalmology RE1-994 Qi Wan Zhi-Yong Zhang Shuo Yang Role of surfactant proteins in viral keratitis
description	Innate immunity plays an important role in viral keratitis. Recently, it has been found that surfactant proteins(SP)A and D in the innate immune system are essential in viral keratitis. SP can inhibit virus adhesion to host cells and further promote phagocytosis of virus through high affinity for virus ligands. In order to ensure the normal function of tissues in the early stage of virus infection, SP regulates immune cells to maintain a non-inflammatory state. However, when pathogen invasion increases, SP promoted inflammation and increased the immune cells to kill the pathogens. SP-A and SP-D could be expressed in cornea, conjunctiva. To play the role of anti-adenovirus, herpes simplex virus, cytomegalovirus and other major eye pathogenic viruses, SP-A and SP-D combine with the virus to prevent entry into cells, promote phagocytosis, and directly kill the virus. SP-A and SP-D may be used as clinical diagnostic tools for viral infection. In the future, recombinant SP is expected to be used as an important means for the treatment of viral keratitis. Here, we review the innate immune function of SP-A and SP-D in ocular viral infection.
format	article
author	Qi Wan Zhi-Yong Zhang Shuo Yang
author_facet	Qi Wan Zhi-Yong Zhang Shuo Yang
author_sort	Qi Wan
title	Role of surfactant proteins in viral keratitis
title_short	Role of surfactant proteins in viral keratitis
title_full	Role of surfactant proteins in viral keratitis
title_fullStr	Role of surfactant proteins in viral keratitis
title_full_unstemmed	Role of surfactant proteins in viral keratitis
title_sort	role of surfactant proteins in viral keratitis
publisher	Press of International Journal of Ophthalmology (IJO PRESS)
publishDate	2021
url	https://doaj.org/article/d6b24f489f5e40ecb232c87cf430fa78
work_keys_str_mv	AT qiwan roleofsurfactantproteinsinviralkeratitis AT zhiyongzhang roleofsurfactantproteinsinviralkeratitis AT shuoyang roleofsurfactantproteinsinviralkeratitis
_version_	1718417581534085120

Role of surfactant proteins in viral keratitis

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