A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection

A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection

Extracellular vesicles (EV)-associated RNAs are serum biomarkers potentially exploitable for early cancer diagnosis. Here the authors develop a catalyzed hairpin DNA circuit within a cationic lipid-polymer hybrid nanoparticle that can detect low–level EV-associated RNAs in early stage cancer patient...

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Autores principales: Jiaming Hu, Yan Sheng, Kwang Joo Kwak, Junfeng Shi, Bohao Yu, L. James Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/d6b3646ce5fc48d5b9f7ede81940464d
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spelling oai:doaj.org-article:d6b3646ce5fc48d5b9f7ede81940464d2021-12-02T17:06:26ZA signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection10.1038/s41467-017-01942-12041-1723https://doaj.org/article/d6b3646ce5fc48d5b9f7ede81940464d2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01942-1https://doaj.org/toc/2041-1723Extracellular vesicles (EV)-associated RNAs are serum biomarkers potentially exploitable for early cancer diagnosis. Here the authors develop a catalyzed hairpin DNA circuit within a cationic lipid-polymer hybrid nanoparticle that can detect low–level EV-associated RNAs in early stage cancer patients.Jiaming HuYan ShengKwang Joo KwakJunfeng ShiBohao YuL. James LeeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jiaming Hu
Yan Sheng
Kwang Joo Kwak
Junfeng Shi
Bohao Yu
L. James Lee
A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection
description Extracellular vesicles (EV)-associated RNAs are serum biomarkers potentially exploitable for early cancer diagnosis. Here the authors develop a catalyzed hairpin DNA circuit within a cationic lipid-polymer hybrid nanoparticle that can detect low–level EV-associated RNAs in early stage cancer patients.
format article
author Jiaming Hu
Yan Sheng
Kwang Joo Kwak
Junfeng Shi
Bohao Yu
L. James Lee
author_facet Jiaming Hu
Yan Sheng
Kwang Joo Kwak
Junfeng Shi
Bohao Yu
L. James Lee
author_sort Jiaming Hu
title A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection
title_short A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection
title_full A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection
title_fullStr A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection
title_full_unstemmed A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection
title_sort signal-amplifiable biochip quantifies extracellular vesicle-associated rnas for early cancer detection
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/d6b3646ce5fc48d5b9f7ede81940464d
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