Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss

Proprotein convertases subtilisin kexins are serine endoproteases, playing critical roles in the biological functions, including lipid, glucose, and bile acid metabolism, as well as cell proliferation, migration, and metastasis. Experimental studies have demonstrated the physiological functions of P...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Najmeh Parvaz, Zahra Jalali
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d6b61b4c17f94c1ea9c20e994b59b006
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d6b61b4c17f94c1ea9c20e994b59b006
record_format	dspace
spelling	oai:doaj.org-article:d6b61b4c17f94c1ea9c20e994b59b0062021-11-04T06:49:32ZMolecular evolution of PCSK family: Analysis of natural selection rate and gene loss1932-6203https://doaj.org/article/d6b61b4c17f94c1ea9c20e994b59b0062021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553125/?tool=EBIhttps://doaj.org/toc/1932-6203Proprotein convertases subtilisin kexins are serine endoproteases, playing critical roles in the biological functions, including lipid, glucose, and bile acid metabolism, as well as cell proliferation, migration, and metastasis. Experimental studies have demonstrated the physiological functions of PCSKs and their association with diseases; however, studies on the evolutionary history and diversification of these proteins are missing. In the present research, a bioinformatics study was conducted on the molecular evolution of several PCSKs family members and gene loss events across placental mammalian. In order to detect evolutionary constraints and positive selection, the CodeML program of the PAML package was used. The results showed the positive selection to occur in PCSK1, PCSK3, PCSK5, and PCSK7. A decelerated rate of evolution was observed in PCSK7, PCSK3, and MBTPS1 in Carnivores compared to the rest of phylogeny, and an accelerated evolution of PCSK1, PCSK7, and MBTPS1 in Muridae family of rodents was found. Additionally, our results indicated pcsk9 gene loss in 12 species comprising Carnivores and bats (Chiroptera). Future studies are required to evaluate the functional relevance and selective evolutionary advantages associated with these modifications in PCSK proteins during evolution.Najmeh ParvazZahra JalaliPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Najmeh Parvaz Zahra Jalali Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss
description	Proprotein convertases subtilisin kexins are serine endoproteases, playing critical roles in the biological functions, including lipid, glucose, and bile acid metabolism, as well as cell proliferation, migration, and metastasis. Experimental studies have demonstrated the physiological functions of PCSKs and their association with diseases; however, studies on the evolutionary history and diversification of these proteins are missing. In the present research, a bioinformatics study was conducted on the molecular evolution of several PCSKs family members and gene loss events across placental mammalian. In order to detect evolutionary constraints and positive selection, the CodeML program of the PAML package was used. The results showed the positive selection to occur in PCSK1, PCSK3, PCSK5, and PCSK7. A decelerated rate of evolution was observed in PCSK7, PCSK3, and MBTPS1 in Carnivores compared to the rest of phylogeny, and an accelerated evolution of PCSK1, PCSK7, and MBTPS1 in Muridae family of rodents was found. Additionally, our results indicated pcsk9 gene loss in 12 species comprising Carnivores and bats (Chiroptera). Future studies are required to evaluate the functional relevance and selective evolutionary advantages associated with these modifications in PCSK proteins during evolution.
format	article
author	Najmeh Parvaz Zahra Jalali
author_facet	Najmeh Parvaz Zahra Jalali
author_sort	Najmeh Parvaz
title	Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss
title_short	Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss
title_full	Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss
title_fullStr	Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss
title_full_unstemmed	Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss
title_sort	molecular evolution of pcsk family: analysis of natural selection rate and gene loss
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d6b61b4c17f94c1ea9c20e994b59b006
work_keys_str_mv	AT najmehparvaz molecularevolutionofpcskfamilyanalysisofnaturalselectionrateandgeneloss AT zahrajalali molecularevolutionofpcskfamilyanalysisofnaturalselectionrateandgeneloss
_version_	1718445119552618496

Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss

Ejemplares similares