Beyond identity: Understanding the contribution of the 5' nucleotide of the antisense strand to RNAi activity.

Beyond identity: Understanding the contribution of the 5' nucleotide of the antisense strand to RNAi activity.

In both the pharmaceutical and agricultural fields, RNA-based products have capitalized upon the mechanism of RNA interference for targeted reduction of gene expression to improve phenotypes and traits. Reduction in gene expression by RNAi is the result of a small interfering RNA (siRNA) molecule bi...

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Autores principales: Peizhen Yang, Ericka Havecker, Matthew Bauer, Carl Diehl, Bill Hendrix, Paul Hoffer, Timothy Boyle, John Bradley, Amy Caruano-Yzermans, Jill Deikman
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/d6b92fba9dea4747ac97c7f203ecb861
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