Dynamic reconfiguration of cortical functional connectivity across brain states

Abstract Throughout each day, the brain displays transient changes in state, as evidenced by shifts in behavior and vigilance. While the electrophysiological correlates of brain states have been studied for some time, it remains unclear how large-scale cortico-cortical functional connectivity system...

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Autores principales:	Iain Stitt, Karl J. Hollensteiner, Edgar Galindo-Leon, Florian Pieper, Eva Fiedler, Thomas Stieglitz, Gerhard Engler, Guido Nolte, Andreas K. Engel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d6bbf2d26391475a834fc1030316ab6a
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spelling	oai:doaj.org-article:d6bbf2d26391475a834fc1030316ab6a2021-12-02T16:06:49ZDynamic reconfiguration of cortical functional connectivity across brain states10.1038/s41598-017-08050-62045-2322https://doaj.org/article/d6bbf2d26391475a834fc1030316ab6a2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08050-6https://doaj.org/toc/2045-2322Abstract Throughout each day, the brain displays transient changes in state, as evidenced by shifts in behavior and vigilance. While the electrophysiological correlates of brain states have been studied for some time, it remains unclear how large-scale cortico-cortical functional connectivity systematically reconfigures across states. Here, we investigate state-dependent shifts in cortical functional connectivity by recording local field potentials (LFPs) during spontaneous behavioral transitions in the ferret using chronically implanted micro-electrocorticographic (µECoG) arrays positioned over occipital, parietal, and temporal cortical regions. To objectively classify brain state, we describe a data-driven approach that projects time-varying LFP spectral properties into brain state space. Distinct brain states displayed markedly different patterns of cross-frequency phase-amplitude coupling and inter-electrode phase synchronization across several LFP frequency bands. The largest across-state differences in functional connectivity were observed between periods of presumed slow-wave and rapid-eye-movement-sleep/active-state, which were characterized by the contrasting phenomena of cortical network fragmentation and global synchronization, respectively. Collectively, our data provide strong evidence that large-scale functional interactions in the brain dynamically reconfigure across behavioral states.Iain StittKarl J. HollensteinerEdgar Galindo-LeonFlorian PieperEva FiedlerThomas StieglitzGerhard EnglerGuido NolteAndreas K. EngelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Iain Stitt Karl J. Hollensteiner Edgar Galindo-Leon Florian Pieper Eva Fiedler Thomas Stieglitz Gerhard Engler Guido Nolte Andreas K. Engel Dynamic reconfiguration of cortical functional connectivity across brain states
description	Abstract Throughout each day, the brain displays transient changes in state, as evidenced by shifts in behavior and vigilance. While the electrophysiological correlates of brain states have been studied for some time, it remains unclear how large-scale cortico-cortical functional connectivity systematically reconfigures across states. Here, we investigate state-dependent shifts in cortical functional connectivity by recording local field potentials (LFPs) during spontaneous behavioral transitions in the ferret using chronically implanted micro-electrocorticographic (µECoG) arrays positioned over occipital, parietal, and temporal cortical regions. To objectively classify brain state, we describe a data-driven approach that projects time-varying LFP spectral properties into brain state space. Distinct brain states displayed markedly different patterns of cross-frequency phase-amplitude coupling and inter-electrode phase synchronization across several LFP frequency bands. The largest across-state differences in functional connectivity were observed between periods of presumed slow-wave and rapid-eye-movement-sleep/active-state, which were characterized by the contrasting phenomena of cortical network fragmentation and global synchronization, respectively. Collectively, our data provide strong evidence that large-scale functional interactions in the brain dynamically reconfigure across behavioral states.
format	article
author	Iain Stitt Karl J. Hollensteiner Edgar Galindo-Leon Florian Pieper Eva Fiedler Thomas Stieglitz Gerhard Engler Guido Nolte Andreas K. Engel
author_facet	Iain Stitt Karl J. Hollensteiner Edgar Galindo-Leon Florian Pieper Eva Fiedler Thomas Stieglitz Gerhard Engler Guido Nolte Andreas K. Engel
author_sort	Iain Stitt
title	Dynamic reconfiguration of cortical functional connectivity across brain states
title_short	Dynamic reconfiguration of cortical functional connectivity across brain states
title_full	Dynamic reconfiguration of cortical functional connectivity across brain states
title_fullStr	Dynamic reconfiguration of cortical functional connectivity across brain states
title_full_unstemmed	Dynamic reconfiguration of cortical functional connectivity across brain states
title_sort	dynamic reconfiguration of cortical functional connectivity across brain states
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d6bbf2d26391475a834fc1030316ab6a
work_keys_str_mv	AT iainstitt dynamicreconfigurationofcorticalfunctionalconnectivityacrossbrainstates AT karljhollensteiner dynamicreconfigurationofcorticalfunctionalconnectivityacrossbrainstates AT edgargalindoleon dynamicreconfigurationofcorticalfunctionalconnectivityacrossbrainstates AT florianpieper dynamicreconfigurationofcorticalfunctionalconnectivityacrossbrainstates AT evafiedler dynamicreconfigurationofcorticalfunctionalconnectivityacrossbrainstates AT thomasstieglitz dynamicreconfigurationofcorticalfunctionalconnectivityacrossbrainstates AT gerhardengler dynamicreconfigurationofcorticalfunctionalconnectivityacrossbrainstates AT guidonolte dynamicreconfigurationofcorticalfunctionalconnectivityacrossbrainstates AT andreaskengel dynamicreconfigurationofcorticalfunctionalconnectivityacrossbrainstates
_version_	1718384871400800256

Dynamic reconfiguration of cortical functional connectivity across brain states

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