Plasma Levels of Fetuin B and Fibrinogen in Chronic Obstructive Pulmonary Disease: A Preliminary Cross-sectional Study
Introduction: Recent exploratory proteomics study reported increased blood levels of Fetuin B (FETUB) in Chronic Obstructive Pulmonary Disease (COPD). Growing body of evidence demonstrates fibrinogen not only as acute phase reactant but also possesses features advocating as biomarker of COPD....
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
JCDR Research and Publications Private Limited
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/d6be8d5f8b1d45da8897b80f0e0f5e6f |
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| Sumario: | Introduction: Recent exploratory proteomics study reported
increased blood levels of Fetuin B (FETUB) in Chronic
Obstructive Pulmonary Disease (COPD). Growing body of
evidence demonstrates fibrinogen not only as acute phase
reactant but also possesses features advocating as biomarker
of COPD.
Aim: To determine the blood levels of FETUB and fibrinogen
independently as well as in combination COPD and among
severity of COPD.
Materials and Methods: A single-centred cross-sectional study of
eight months duration was conducted during May to December
2017. A total of 76 blood samples (38 COPD patients and 38
controls) were recruited. Based on distribution, parametric and non
parametric statistical tools were used. Analysis of co-variance and
multiple multivariate linear regression models were utilised to assess
the influence of clinical data on FETUB. Steel-Dwass-CritchlowFligner method was employed for multiple pairwise comparisons.
Receiver Operating Characteristic (ROC) curve were generated to
compute cut-off of FETUB, fibrinogen and their combination.
Results: The median age of subjects were 57 years with an IQR
of 50-66 years for controls whereas 58 years (IQR 50-65 years)
for COPD subjects. In comparison to controls, a significant
increase in blood levels of both FETUB and fibrinogen in COPD
and Global Initiative for Chronic Obstructive Lung Disease
(GOLD) stages of COPD was prominent. Among COPD grades,
differences of FETUB levels were significant in GOLD I vs II and
GOLD IV vs I, II and III whereas fibrinogen levels in GOLD III
from GOLD IV. FETUB showed independent correlation with
Forced Expiratory Volume (FEV) 1% pred and severity of COPD.
A moderate improvement in combined (FETUB+fibrinogen)
analysis of control vs COPD was noticed.
Conclusion: The present study demonstrates significant increase
in blood levels of FETUB in COPD and among the severity of
COPD in comparison to fibrinogen. Hence, FETUB can be a more
promising probable inflammatory biomarker in COPD. |
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