A short translational ramp determines the efficiency of protein synthesis

Several factors contribute to the efficiency of protein expression. Here the authors show that the identity of amino acids encoded by codons at position 3–5 significantly impact translation efficiency and protein expression levels.

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Autores principales:	Manasvi Verma, Junhong Choi, Kyle A. Cottrell, Zeno Lavagnino, Erica N. Thomas, Slavica Pavlovic-Djuranovic, Pawel Szczesny, David W. Piston, Hani S. Zaher, Joseph D. Puglisi, Sergej Djuranovic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d6c7739bcd3d4753818faecc0bc65dc2
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spelling	oai:doaj.org-article:d6c7739bcd3d4753818faecc0bc65dc22021-12-02T13:27:31ZA short translational ramp determines the efficiency of protein synthesis10.1038/s41467-019-13810-12041-1723https://doaj.org/article/d6c7739bcd3d4753818faecc0bc65dc22019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13810-1https://doaj.org/toc/2041-1723Several factors contribute to the efficiency of protein expression. Here the authors show that the identity of amino acids encoded by codons at position 3–5 significantly impact translation efficiency and protein expression levels.Manasvi VermaJunhong ChoiKyle A. CottrellZeno LavagninoErica N. ThomasSlavica Pavlovic-DjuranovicPawel SzczesnyDavid W. PistonHani S. ZaherJoseph D. PuglisiSergej DjuranovicNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manasvi Verma Junhong Choi Kyle A. Cottrell Zeno Lavagnino Erica N. Thomas Slavica Pavlovic-Djuranovic Pawel Szczesny David W. Piston Hani S. Zaher Joseph D. Puglisi Sergej Djuranovic A short translational ramp determines the efficiency of protein synthesis
description	Several factors contribute to the efficiency of protein expression. Here the authors show that the identity of amino acids encoded by codons at position 3–5 significantly impact translation efficiency and protein expression levels.
format	article
author	Manasvi Verma Junhong Choi Kyle A. Cottrell Zeno Lavagnino Erica N. Thomas Slavica Pavlovic-Djuranovic Pawel Szczesny David W. Piston Hani S. Zaher Joseph D. Puglisi Sergej Djuranovic
author_facet	Manasvi Verma Junhong Choi Kyle A. Cottrell Zeno Lavagnino Erica N. Thomas Slavica Pavlovic-Djuranovic Pawel Szczesny David W. Piston Hani S. Zaher Joseph D. Puglisi Sergej Djuranovic
author_sort	Manasvi Verma
title	A short translational ramp determines the efficiency of protein synthesis
title_short	A short translational ramp determines the efficiency of protein synthesis
title_full	A short translational ramp determines the efficiency of protein synthesis
title_fullStr	A short translational ramp determines the efficiency of protein synthesis
title_full_unstemmed	A short translational ramp determines the efficiency of protein synthesis
title_sort	short translational ramp determines the efficiency of protein synthesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d6c7739bcd3d4753818faecc0bc65dc2
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A short translational ramp determines the efficiency of protein synthesis

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