Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases
Chronic inflammation plays a significant role in lifestyle-related diseases, such as cardiovascular diseases and obesity/impaired glucose tolerance. Curcumin is a natural extract that possesses numerous physiological properties, as indicated by its anti-inflammatory action. The mechanisms underlying...
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Radcliffe Medical Media
2019
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oai:doaj.org-article:d6c9b3f2fc46444f8f0fb0730eb6f66b2021-12-04T16:01:42ZAnti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases10.15420/ecr.2019.17.21758-37641758-3756https://doaj.org/article/d6c9b3f2fc46444f8f0fb0730eb6f66b2019-07-01T00:00:00Zhttps://www.ecrjournal.com/articles/anti-inflammatory-action-curcumin-usehttps://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764Chronic inflammation plays a significant role in lifestyle-related diseases, such as cardiovascular diseases and obesity/impaired glucose tolerance. Curcumin is a natural extract that possesses numerous physiological properties, as indicated by its anti-inflammatory action. The mechanisms underlying these effects include the inhibition of nuclear factor-kappaB and Toll-like receptor 4-dependent signalling pathways and the activation of a peroxisome proliferator-activated receptor-gamma pathway. However, the bioavailability of curcumin is very low in humans. To resolve this issue, several drug delivery systems have been developed and a number of clinical trials have reported beneficial effects of curcumin in the management of inflammation-related diseases. It is expected that evidence regarding the clinical application of curcumin in lifestyle-related diseases associated with chronic inflammation will accumulate over time.Kana ShimizuMasafumi FunamotoYoichi SunagawaSatoshi ShimizuYasufumi KatanasakaYusuke MiyazakiHiromichi WadaKoji HasegawaTatsuya MorimotoRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 14, Iss 2, Pp 117-122 (2019) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Diseases of the circulatory (Cardiovascular) system RC666-701 |
| spellingShingle |
Diseases of the circulatory (Cardiovascular) system RC666-701 Kana Shimizu Masafumi Funamoto Yoichi Sunagawa Satoshi Shimizu Yasufumi Katanasaka Yusuke Miyazaki Hiromichi Wada Koji Hasegawa Tatsuya Morimoto Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases |
| description |
Chronic inflammation plays a significant role in lifestyle-related diseases, such as cardiovascular diseases and obesity/impaired glucose tolerance. Curcumin is a natural extract that possesses numerous physiological properties, as indicated by its anti-inflammatory action. The mechanisms underlying these effects include the inhibition of nuclear factor-kappaB and Toll-like receptor 4-dependent signalling pathways and the activation of a peroxisome proliferator-activated receptor-gamma pathway. However, the bioavailability of curcumin is very low in humans. To resolve this issue, several drug delivery systems have been developed and a number of clinical trials have reported beneficial effects of curcumin in the management of inflammation-related diseases. It is expected that evidence regarding the clinical application of curcumin in lifestyle-related diseases associated with chronic inflammation will accumulate over time. |
| format |
article |
| author |
Kana Shimizu Masafumi Funamoto Yoichi Sunagawa Satoshi Shimizu Yasufumi Katanasaka Yusuke Miyazaki Hiromichi Wada Koji Hasegawa Tatsuya Morimoto |
| author_facet |
Kana Shimizu Masafumi Funamoto Yoichi Sunagawa Satoshi Shimizu Yasufumi Katanasaka Yusuke Miyazaki Hiromichi Wada Koji Hasegawa Tatsuya Morimoto |
| author_sort |
Kana Shimizu |
| title |
Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases |
| title_short |
Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases |
| title_full |
Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases |
| title_fullStr |
Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases |
| title_full_unstemmed |
Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases |
| title_sort |
anti-inflammatory action of curcumin and its use in the treatment of lifestyle-related diseases |
| publisher |
Radcliffe Medical Media |
| publishDate |
2019 |
| url |
https://doaj.org/article/d6c9b3f2fc46444f8f0fb0730eb6f66b |
| work_keys_str_mv |
AT kanashimizu antiinflammatoryactionofcurcuminanditsuseinthetreatmentoflifestylerelateddiseases AT masafumifunamoto antiinflammatoryactionofcurcuminanditsuseinthetreatmentoflifestylerelateddiseases AT yoichisunagawa antiinflammatoryactionofcurcuminanditsuseinthetreatmentoflifestylerelateddiseases AT satoshishimizu antiinflammatoryactionofcurcuminanditsuseinthetreatmentoflifestylerelateddiseases AT yasufumikatanasaka antiinflammatoryactionofcurcuminanditsuseinthetreatmentoflifestylerelateddiseases AT yusukemiyazaki antiinflammatoryactionofcurcuminanditsuseinthetreatmentoflifestylerelateddiseases AT hiromichiwada antiinflammatoryactionofcurcuminanditsuseinthetreatmentoflifestylerelateddiseases AT kojihasegawa antiinflammatoryactionofcurcuminanditsuseinthetreatmentoflifestylerelateddiseases AT tatsuyamorimoto antiinflammatoryactionofcurcuminanditsuseinthetreatmentoflifestylerelateddiseases |
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