IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

IL-1-mediated inflammation contributes to the pathogenesis of cystic fibrosis. Here the authors show that this is largely due to NLRP3 activation, whereas NLRP4 induces IL-1Ra, limiting the overall inflammasome activity and providing a therapeutic angle to ameliorate the disease.

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Autores principales:	Rossana G. Iannitti, Valerio Napolioni, Vasilis Oikonomou, Antonella De Luca, Claudia Galosi, Marilena Pariano, Cristina Massi-Benedetti, Monica Borghi, Matteo Puccetti, Vincenzina Lucidi, Carla Colombo, Ersilia Fiscarelli, Cornelia Lass-Flörl, Fabio Majo, Lisa Cariani, Maria Russo, Luigi Porcaro, Gabriella Ricciotti, Helmut Ellemunter, Luigi Ratclif, Fernando Maria De Benedictis, Vincenzo Nicola Talesa, Charles A. Dinarello, Frank L. van de Veerdonk, Luigina Romani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d6cc6aeb6fcc484ba0b57ba0dd5dd213
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spelling	oai:doaj.org-article:d6cc6aeb6fcc484ba0b57ba0dd5dd2132021-12-02T16:57:18ZIL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis10.1038/ncomms107912041-1723https://doaj.org/article/d6cc6aeb6fcc484ba0b57ba0dd5dd2132016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10791https://doaj.org/toc/2041-1723IL-1-mediated inflammation contributes to the pathogenesis of cystic fibrosis. Here the authors show that this is largely due to NLRP3 activation, whereas NLRP4 induces IL-1Ra, limiting the overall inflammasome activity and providing a therapeutic angle to ameliorate the disease.Rossana G. IannittiValerio NapolioniVasilis OikonomouAntonella De LucaClaudia GalosiMarilena ParianoCristina Massi-BenedettiMonica BorghiMatteo PuccettiVincenzina LucidiCarla ColomboErsilia FiscarelliCornelia Lass-FlörlFabio MajoLisa CarianiMaria RussoLuigi PorcaroGabriella RicciottiHelmut EllemunterLuigi RatclifFernando Maria De BenedictisVincenzo Nicola TalesaCharles A. DinarelloFrank L. van de VeerdonkLuigina RomaniNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rossana G. Iannitti Valerio Napolioni Vasilis Oikonomou Antonella De Luca Claudia Galosi Marilena Pariano Cristina Massi-Benedetti Monica Borghi Matteo Puccetti Vincenzina Lucidi Carla Colombo Ersilia Fiscarelli Cornelia Lass-Flörl Fabio Majo Lisa Cariani Maria Russo Luigi Porcaro Gabriella Ricciotti Helmut Ellemunter Luigi Ratclif Fernando Maria De Benedictis Vincenzo Nicola Talesa Charles A. Dinarello Frank L. van de Veerdonk Luigina Romani IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis
description	IL-1-mediated inflammation contributes to the pathogenesis of cystic fibrosis. Here the authors show that this is largely due to NLRP3 activation, whereas NLRP4 induces IL-1Ra, limiting the overall inflammasome activity and providing a therapeutic angle to ameliorate the disease.
format	article
author	Rossana G. Iannitti Valerio Napolioni Vasilis Oikonomou Antonella De Luca Claudia Galosi Marilena Pariano Cristina Massi-Benedetti Monica Borghi Matteo Puccetti Vincenzina Lucidi Carla Colombo Ersilia Fiscarelli Cornelia Lass-Flörl Fabio Majo Lisa Cariani Maria Russo Luigi Porcaro Gabriella Ricciotti Helmut Ellemunter Luigi Ratclif Fernando Maria De Benedictis Vincenzo Nicola Talesa Charles A. Dinarello Frank L. van de Veerdonk Luigina Romani
author_facet	Rossana G. Iannitti Valerio Napolioni Vasilis Oikonomou Antonella De Luca Claudia Galosi Marilena Pariano Cristina Massi-Benedetti Monica Borghi Matteo Puccetti Vincenzina Lucidi Carla Colombo Ersilia Fiscarelli Cornelia Lass-Flörl Fabio Majo Lisa Cariani Maria Russo Luigi Porcaro Gabriella Ricciotti Helmut Ellemunter Luigi Ratclif Fernando Maria De Benedictis Vincenzo Nicola Talesa Charles A. Dinarello Frank L. van de Veerdonk Luigina Romani
author_sort	Rossana G. Iannitti
title	IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis
title_short	IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis
title_full	IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis
title_fullStr	IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis
title_full_unstemmed	IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis
title_sort	il-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d6cc6aeb6fcc484ba0b57ba0dd5dd213
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IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

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