DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models

Adoptive T cell therapy using an allogeneic T cell graft is an encouraging therapeutic approach in cancer, but issues such as graft-versus-host disease can hinder applicability. Here, the authors show that DOT1L inhibition or DUSP6 overexpression in T cells attenuates graft-versus-host disease but r...

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Autores principales:	Yuki Kagoya, Munehide Nakatsugawa, Kayoko Saso, Tingxi Guo, Mark Anczurowski, Chung-Hsi Wang, Marcus O. Butler, Cheryl H. Arrowsmith, Naoto Hirano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d6ce55cb15b249f6b173e89e668c2976
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spelling	oai:doaj.org-article:d6ce55cb15b249f6b173e89e668c29762021-12-02T16:49:51ZDOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models10.1038/s41467-018-04262-02041-1723https://doaj.org/article/d6ce55cb15b249f6b173e89e668c29762018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04262-0https://doaj.org/toc/2041-1723Adoptive T cell therapy using an allogeneic T cell graft is an encouraging therapeutic approach in cancer, but issues such as graft-versus-host disease can hinder applicability. Here, the authors show that DOT1L inhibition or DUSP6 overexpression in T cells attenuates graft-versus-host disease but retains anti-tumour activity in mouse models.Yuki KagoyaMunehide NakatsugawaKayoko SasoTingxi GuoMark AnczurowskiChung-Hsi WangMarcus O. ButlerCheryl H. ArrowsmithNaoto HiranoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuki Kagoya Munehide Nakatsugawa Kayoko Saso Tingxi Guo Mark Anczurowski Chung-Hsi Wang Marcus O. Butler Cheryl H. Arrowsmith Naoto Hirano DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models
description	Adoptive T cell therapy using an allogeneic T cell graft is an encouraging therapeutic approach in cancer, but issues such as graft-versus-host disease can hinder applicability. Here, the authors show that DOT1L inhibition or DUSP6 overexpression in T cells attenuates graft-versus-host disease but retains anti-tumour activity in mouse models.
format	article
author	Yuki Kagoya Munehide Nakatsugawa Kayoko Saso Tingxi Guo Mark Anczurowski Chung-Hsi Wang Marcus O. Butler Cheryl H. Arrowsmith Naoto Hirano
author_facet	Yuki Kagoya Munehide Nakatsugawa Kayoko Saso Tingxi Guo Mark Anczurowski Chung-Hsi Wang Marcus O. Butler Cheryl H. Arrowsmith Naoto Hirano
author_sort	Yuki Kagoya
title	DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models
title_short	DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models
title_full	DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models
title_fullStr	DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models
title_full_unstemmed	DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models
title_sort	dot1l inhibition attenuates graft-versus-host disease by allogeneic t cells in adoptive immunotherapy models
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d6ce55cb15b249f6b173e89e668c2976
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DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models

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