A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population
Abstract Numerous genetic variants associated with hypertension and blood pressure are known, but there is a paucity of evidence from genetic studies of resistant hypertension, especially in Asian populations. To identify novel genetic loci associated with resistant hypertension in the Japanese popu...
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Nature Portfolio
2021
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oai:doaj.org-article:d6cf22e3bc8d40b3927f55e2e8aae4a12021-12-02T17:37:40ZA genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population10.1038/s41598-021-98144-z2045-2322https://doaj.org/article/d6cf22e3bc8d40b3927f55e2e8aae4a12021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98144-zhttps://doaj.org/toc/2045-2322Abstract Numerous genetic variants associated with hypertension and blood pressure are known, but there is a paucity of evidence from genetic studies of resistant hypertension, especially in Asian populations. To identify novel genetic loci associated with resistant hypertension in the Japanese population, we conducted a genome-wide association study with 2705 resistant hypertension cases and 21,296 mild hypertension controls, all from BioBank Japan. We identified one novel susceptibility candidate locus, rs1442386 on chromosome 18p11.3 (DLGAP1), achieving genome-wide significance (odds ratio (95% CI) = 0.85 (0.81–0.90), P = 3.75 × 10−8) and 18 loci showing suggestive association, including rs62525059 of 8q24.3 (CYP11B2) and rs3774427 of 3p21.1 (CACNA1D). We further detected biological processes associated with resistant hypertension, including chemical synaptic transmission, regulation of transmembrane transport, neuron development and neurological system processes, highlighting the importance of the nervous system. This study provides insights into the etiology of resistant hypertension in the Japanese population.Yasuo TakahashiKeiko YamazakiYoichiro KamataniMichiaki KuboKoichi MatsudaSatoshi AsaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
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Medicine R Science Q Yasuo Takahashi Keiko Yamazaki Yoichiro Kamatani Michiaki Kubo Koichi Matsuda Satoshi Asai A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population |
| description |
Abstract Numerous genetic variants associated with hypertension and blood pressure are known, but there is a paucity of evidence from genetic studies of resistant hypertension, especially in Asian populations. To identify novel genetic loci associated with resistant hypertension in the Japanese population, we conducted a genome-wide association study with 2705 resistant hypertension cases and 21,296 mild hypertension controls, all from BioBank Japan. We identified one novel susceptibility candidate locus, rs1442386 on chromosome 18p11.3 (DLGAP1), achieving genome-wide significance (odds ratio (95% CI) = 0.85 (0.81–0.90), P = 3.75 × 10−8) and 18 loci showing suggestive association, including rs62525059 of 8q24.3 (CYP11B2) and rs3774427 of 3p21.1 (CACNA1D). We further detected biological processes associated with resistant hypertension, including chemical synaptic transmission, regulation of transmembrane transport, neuron development and neurological system processes, highlighting the importance of the nervous system. This study provides insights into the etiology of resistant hypertension in the Japanese population. |
| format |
article |
| author |
Yasuo Takahashi Keiko Yamazaki Yoichiro Kamatani Michiaki Kubo Koichi Matsuda Satoshi Asai |
| author_facet |
Yasuo Takahashi Keiko Yamazaki Yoichiro Kamatani Michiaki Kubo Koichi Matsuda Satoshi Asai |
| author_sort |
Yasuo Takahashi |
| title |
A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population |
| title_short |
A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population |
| title_full |
A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population |
| title_fullStr |
A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population |
| title_full_unstemmed |
A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population |
| title_sort |
genome-wide association study identifies a novel candidate locus at the dlgap1 gene with susceptibility to resistant hypertension in the japanese population |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d6cf22e3bc8d40b3927f55e2e8aae4a1 |
| work_keys_str_mv |
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