ORAI channels are critical for receptor-mediated endocytosis of albumin

Patients with diabetic nephropathy suffer from impaired albumin reabsorption by proximal tubular epithelial cells. Here authors use diabetic and transgenic mouse models and in vitro models to show the cause for this lies in the down regulation and internalization of the ion channels, ORAI1-3.

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Autores principales:	Bo Zeng, Gui-Lan Chen, Eliana Garcia-Vaz, Sunil Bhandari, Nikoleta Daskoulidou, Lisa M. Berglund, Hongni Jiang, Thomas Hallett, Lu-Ping Zhou, Li Huang, Zi-Hao Xu, Viji Nair, Robert G. Nelson, Wenjun Ju, Matthias Kretzler, Stephen L. Atkin, Maria F. Gomez, Shang-Zhong Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d6d1cb0bcd8f49c9b88f64376cab64f6
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spelling	oai:doaj.org-article:d6d1cb0bcd8f49c9b88f64376cab64f62021-12-02T17:01:23ZORAI channels are critical for receptor-mediated endocytosis of albumin10.1038/s41467-017-02094-y2041-1723https://doaj.org/article/d6d1cb0bcd8f49c9b88f64376cab64f62017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02094-yhttps://doaj.org/toc/2041-1723Patients with diabetic nephropathy suffer from impaired albumin reabsorption by proximal tubular epithelial cells. Here authors use diabetic and transgenic mouse models and in vitro models to show the cause for this lies in the down regulation and internalization of the ion channels, ORAI1-3.Bo ZengGui-Lan ChenEliana Garcia-VazSunil BhandariNikoleta DaskoulidouLisa M. BerglundHongni JiangThomas HallettLu-Ping ZhouLi HuangZi-Hao XuViji NairRobert G. NelsonWenjun JuMatthias KretzlerStephen L. AtkinMaria F. GomezShang-Zhong XuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bo Zeng Gui-Lan Chen Eliana Garcia-Vaz Sunil Bhandari Nikoleta Daskoulidou Lisa M. Berglund Hongni Jiang Thomas Hallett Lu-Ping Zhou Li Huang Zi-Hao Xu Viji Nair Robert G. Nelson Wenjun Ju Matthias Kretzler Stephen L. Atkin Maria F. Gomez Shang-Zhong Xu ORAI channels are critical for receptor-mediated endocytosis of albumin
description	Patients with diabetic nephropathy suffer from impaired albumin reabsorption by proximal tubular epithelial cells. Here authors use diabetic and transgenic mouse models and in vitro models to show the cause for this lies in the down regulation and internalization of the ion channels, ORAI1-3.
format	article
author	Bo Zeng Gui-Lan Chen Eliana Garcia-Vaz Sunil Bhandari Nikoleta Daskoulidou Lisa M. Berglund Hongni Jiang Thomas Hallett Lu-Ping Zhou Li Huang Zi-Hao Xu Viji Nair Robert G. Nelson Wenjun Ju Matthias Kretzler Stephen L. Atkin Maria F. Gomez Shang-Zhong Xu
author_facet	Bo Zeng Gui-Lan Chen Eliana Garcia-Vaz Sunil Bhandari Nikoleta Daskoulidou Lisa M. Berglund Hongni Jiang Thomas Hallett Lu-Ping Zhou Li Huang Zi-Hao Xu Viji Nair Robert G. Nelson Wenjun Ju Matthias Kretzler Stephen L. Atkin Maria F. Gomez Shang-Zhong Xu
author_sort	Bo Zeng
title	ORAI channels are critical for receptor-mediated endocytosis of albumin
title_short	ORAI channels are critical for receptor-mediated endocytosis of albumin
title_full	ORAI channels are critical for receptor-mediated endocytosis of albumin
title_fullStr	ORAI channels are critical for receptor-mediated endocytosis of albumin
title_full_unstemmed	ORAI channels are critical for receptor-mediated endocytosis of albumin
title_sort	orai channels are critical for receptor-mediated endocytosis of albumin
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d6d1cb0bcd8f49c9b88f64376cab64f6
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ORAI channels are critical for receptor-mediated endocytosis of albumin

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