Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways

Chlorpyrifos (CPF) has been widely used around the world as a pesticide for both agricultural and residential application. Although various studies have reported toxicity and health-related effects from CPF exposure, the potential threat and the molecular mechanism of CPF toxicity to human liver hav...

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Autores principales:	Yang Zhang, Yuansen Chang, Haijing Cao, Wenping Xu, Zhong Li, Liming Tao
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	pesticide chlorpyrifos human liver cells cytotoxic effects the mitochondrial apoptosis pathway Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d6d261cd049a4063bfabe690c3329ac8
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spelling	oai:doaj.org-article:d6d261cd049a4063bfabe690c3329ac82021-11-26T11:19:46ZPotential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways0954-01051465-344310.1080/09540105.2017.1373271https://doaj.org/article/d6d261cd049a4063bfabe690c3329ac82018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2017.1373271https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443Chlorpyrifos (CPF) has been widely used around the world as a pesticide for both agricultural and residential application. Although various studies have reported toxicity and health-related effects from CPF exposure, the potential threat and the molecular mechanism of CPF toxicity to human liver have not been well-characterized. In this study, we identify cytotoxicity of CPF to human normal liver cells in vitro. We demonstrate that the viability of QSG7701 cells is inhibited by CPF in a time- and concentration-dependent manner. Intracellular biochemical assays showed that CPF-induced apoptosis of QSG7701 cells concurrent with a decrease in the mitochondrial membrane potential, the release of cytochrome c into the cytosol, up-regulate the expression level of Bax/Bcl-2 and a marked activation of caspase-9/-3. These results indicate that CPF has a potential risk to human liver that can induce apoptosis of human liver cells through caspase-dependent mitochondrial pathways.Yang ZhangYuansen ChangHaijing CaoWenping XuZhong LiLiming TaoTaylor & Francis Grouparticlepesticidechlorpyrifoshuman liver cellscytotoxic effectsthe mitochondrial apoptosis pathwayAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 294-305 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	pesticide chlorpyrifos human liver cells cytotoxic effects the mitochondrial apoptosis pathway Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	pesticide chlorpyrifos human liver cells cytotoxic effects the mitochondrial apoptosis pathway Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Yang Zhang Yuansen Chang Haijing Cao Wenping Xu Zhong Li Liming Tao Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways
description	Chlorpyrifos (CPF) has been widely used around the world as a pesticide for both agricultural and residential application. Although various studies have reported toxicity and health-related effects from CPF exposure, the potential threat and the molecular mechanism of CPF toxicity to human liver have not been well-characterized. In this study, we identify cytotoxicity of CPF to human normal liver cells in vitro. We demonstrate that the viability of QSG7701 cells is inhibited by CPF in a time- and concentration-dependent manner. Intracellular biochemical assays showed that CPF-induced apoptosis of QSG7701 cells concurrent with a decrease in the mitochondrial membrane potential, the release of cytochrome c into the cytosol, up-regulate the expression level of Bax/Bcl-2 and a marked activation of caspase-9/-3. These results indicate that CPF has a potential risk to human liver that can induce apoptosis of human liver cells through caspase-dependent mitochondrial pathways.
format	article
author	Yang Zhang Yuansen Chang Haijing Cao Wenping Xu Zhong Li Liming Tao
author_facet	Yang Zhang Yuansen Chang Haijing Cao Wenping Xu Zhong Li Liming Tao
author_sort	Yang Zhang
title	Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways
title_short	Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways
title_full	Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways
title_fullStr	Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways
title_full_unstemmed	Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways
title_sort	potential threat of chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/d6d261cd049a4063bfabe690c3329ac8
work_keys_str_mv	AT yangzhang potentialthreatofchlorpyrifostohumanlivercellsviathecaspasedependentmitochondrialpathways AT yuansenchang potentialthreatofchlorpyrifostohumanlivercellsviathecaspasedependentmitochondrialpathways AT haijingcao potentialthreatofchlorpyrifostohumanlivercellsviathecaspasedependentmitochondrialpathways AT wenpingxu potentialthreatofchlorpyrifostohumanlivercellsviathecaspasedependentmitochondrialpathways AT zhongli potentialthreatofchlorpyrifostohumanlivercellsviathecaspasedependentmitochondrialpathways AT limingtao potentialthreatofchlorpyrifostohumanlivercellsviathecaspasedependentmitochondrialpathways
_version_	1718409563591409664

Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways

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