YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion

Cells in many tissues fuse into syncytia acquiring new functions. By investigating whether physical remodelling promotes differentiation, here, the authors show that plasma membrane diminution post-fusion causes transient nutrient stress that inhibits YAP1 activity and may reduce proliferation-promo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Daniel Feliciano, Carolyn M. Ott, Isabel Espinosa-Medina, Aubrey V. Weigel, Lorena Benedetti, Kristin M. Milano, Zhonghua Tang, Tzumin Lee, Harvey J. Kliman, Seth M. Guller, Jennifer Lippincott-Schwartz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d6d425d62b8e4205a0ee1957f8d2d03b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d6d425d62b8e4205a0ee1957f8d2d03b
record_format	dspace
spelling	oai:doaj.org-article:d6d425d62b8e4205a0ee1957f8d2d03b2021-12-02T16:17:53ZYAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion10.1038/s41467-021-24708-22041-1723https://doaj.org/article/d6d425d62b8e4205a0ee1957f8d2d03b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24708-2https://doaj.org/toc/2041-1723Cells in many tissues fuse into syncytia acquiring new functions. By investigating whether physical remodelling promotes differentiation, here, the authors show that plasma membrane diminution post-fusion causes transient nutrient stress that inhibits YAP1 activity and may reduce proliferation-promoting transcription.Daniel FelicianoCarolyn M. OttIsabel Espinosa-MedinaAubrey V. WeigelLorena BenedettiKristin M. MilanoZhonghua TangTzumin LeeHarvey J. KlimanSeth M. GullerJennifer Lippincott-SchwartzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Feliciano Carolyn M. Ott Isabel Espinosa-Medina Aubrey V. Weigel Lorena Benedetti Kristin M. Milano Zhonghua Tang Tzumin Lee Harvey J. Kliman Seth M. Guller Jennifer Lippincott-Schwartz YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion
description	Cells in many tissues fuse into syncytia acquiring new functions. By investigating whether physical remodelling promotes differentiation, here, the authors show that plasma membrane diminution post-fusion causes transient nutrient stress that inhibits YAP1 activity and may reduce proliferation-promoting transcription.
format	article
author	Daniel Feliciano Carolyn M. Ott Isabel Espinosa-Medina Aubrey V. Weigel Lorena Benedetti Kristin M. Milano Zhonghua Tang Tzumin Lee Harvey J. Kliman Seth M. Guller Jennifer Lippincott-Schwartz
author_facet	Daniel Feliciano Carolyn M. Ott Isabel Espinosa-Medina Aubrey V. Weigel Lorena Benedetti Kristin M. Milano Zhonghua Tang Tzumin Lee Harvey J. Kliman Seth M. Guller Jennifer Lippincott-Schwartz
author_sort	Daniel Feliciano
title	YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion
title_short	YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion
title_full	YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion
title_fullStr	YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion
title_full_unstemmed	YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion
title_sort	yap1 nuclear efflux and transcriptional reprograming follow membrane diminution upon vsv-g-induced cell fusion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d6d425d62b8e4205a0ee1957f8d2d03b
work_keys_str_mv	AT danielfeliciano yap1nucleareffluxandtranscriptionalreprogramingfollowmembranediminutionuponvsvginducedcellfusion AT carolynmott yap1nucleareffluxandtranscriptionalreprogramingfollowmembranediminutionuponvsvginducedcellfusion AT isabelespinosamedina yap1nucleareffluxandtranscriptionalreprogramingfollowmembranediminutionuponvsvginducedcellfusion AT aubreyvweigel yap1nucleareffluxandtranscriptionalreprogramingfollowmembranediminutionuponvsvginducedcellfusion AT lorenabenedetti yap1nucleareffluxandtranscriptionalreprogramingfollowmembranediminutionuponvsvginducedcellfusion AT kristinmmilano yap1nucleareffluxandtranscriptionalreprogramingfollowmembranediminutionuponvsvginducedcellfusion AT zhonghuatang yap1nucleareffluxandtranscriptionalreprogramingfollowmembranediminutionuponvsvginducedcellfusion AT tzuminlee yap1nucleareffluxandtranscriptionalreprogramingfollowmembranediminutionuponvsvginducedcellfusion AT harveyjkliman yap1nucleareffluxandtranscriptionalreprogramingfollowmembranediminutionuponvsvginducedcellfusion AT sethmguller yap1nucleareffluxandtranscriptionalreprogramingfollowmembranediminutionuponvsvginducedcellfusion AT jenniferlippincottschwartz yap1nucleareffluxandtranscriptionalreprogramingfollowmembranediminutionuponvsvginducedcellfusion
_version_	1718384258898198528

YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion

Ejemplares similares