Listeriolysin S, a novel peptide haemolysin associated with a subset of lineage I Listeria monocytogenes.

Streptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. Although it has long been thought th...

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Autores principales:	Paul D Cotter, Lorraine A Draper, Elaine M Lawton, Karen M Daly, David S Groeger, Pat G Casey, R Paul Ross, Colin Hill
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d6d55186174b4353bd210caac2e26d86
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spelling	oai:doaj.org-article:d6d55186174b4353bd210caac2e26d862021-11-25T05:47:28ZListeriolysin S, a novel peptide haemolysin associated with a subset of lineage I Listeria monocytogenes.1553-73661553-737410.1371/journal.ppat.1000144https://doaj.org/article/d6d55186174b4353bd210caac2e26d862008-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18787690/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Streptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. Although it has long been thought that SLS and related peptides are produced by GAS and related streptococci only, there is evidence to suggest that a number of the most notorious Gram-positive pathogenic bacteria, including Listeria monocytogenes, Clostridium botulinum and Staphylococcus aureus, produce related peptides. The distribution of the L. monocytogenes cluster is particularly noteworthy in that it is found exclusively among a subset of lineage I strains; i.e., those responsible for the majority of outbreaks of listeriosis. Expression of these genes results in the production of a haemolytic and cytotoxic factor, designated Listeriolysin S, which contributes to virulence of the pathogen as assessed by murine- and human polymorphonuclear neutrophil-based studies. Thus, in the process of establishing the existence of an extended family of SLS-like modified virulence peptides (MVPs), the genetic basis for the enhanced virulence of a proportion of lineage I L. monocytogenes may have been revealed.Paul D CotterLorraine A DraperElaine M LawtonKaren M DalyDavid S GroegerPat G CaseyR Paul RossColin HillPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 4, Iss 9, p e1000144 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Paul D Cotter Lorraine A Draper Elaine M Lawton Karen M Daly David S Groeger Pat G Casey R Paul Ross Colin Hill Listeriolysin S, a novel peptide haemolysin associated with a subset of lineage I Listeria monocytogenes.
description	Streptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. Although it has long been thought that SLS and related peptides are produced by GAS and related streptococci only, there is evidence to suggest that a number of the most notorious Gram-positive pathogenic bacteria, including Listeria monocytogenes, Clostridium botulinum and Staphylococcus aureus, produce related peptides. The distribution of the L. monocytogenes cluster is particularly noteworthy in that it is found exclusively among a subset of lineage I strains; i.e., those responsible for the majority of outbreaks of listeriosis. Expression of these genes results in the production of a haemolytic and cytotoxic factor, designated Listeriolysin S, which contributes to virulence of the pathogen as assessed by murine- and human polymorphonuclear neutrophil-based studies. Thus, in the process of establishing the existence of an extended family of SLS-like modified virulence peptides (MVPs), the genetic basis for the enhanced virulence of a proportion of lineage I L. monocytogenes may have been revealed.
format	article
author	Paul D Cotter Lorraine A Draper Elaine M Lawton Karen M Daly David S Groeger Pat G Casey R Paul Ross Colin Hill
author_facet	Paul D Cotter Lorraine A Draper Elaine M Lawton Karen M Daly David S Groeger Pat G Casey R Paul Ross Colin Hill
author_sort	Paul D Cotter
title	Listeriolysin S, a novel peptide haemolysin associated with a subset of lineage I Listeria monocytogenes.
title_short	Listeriolysin S, a novel peptide haemolysin associated with a subset of lineage I Listeria monocytogenes.
title_full	Listeriolysin S, a novel peptide haemolysin associated with a subset of lineage I Listeria monocytogenes.
title_fullStr	Listeriolysin S, a novel peptide haemolysin associated with a subset of lineage I Listeria monocytogenes.
title_full_unstemmed	Listeriolysin S, a novel peptide haemolysin associated with a subset of lineage I Listeria monocytogenes.
title_sort	listeriolysin s, a novel peptide haemolysin associated with a subset of lineage i listeria monocytogenes.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/d6d55186174b4353bd210caac2e26d86
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Listeriolysin S, a novel peptide haemolysin associated with a subset of lineage I Listeria monocytogenes.

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