Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin

Skin aging is a complex process influenced by intrinsic and extrinsic factors. Together, these factors affect the structure and function of the epidermis and dermis. Histologically, aging skin typically shows epidermal atrophy due to decreased cell numbers. The dermis of aged skin shows decreased nu...

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Autores principales:	Hyunji Lee, Yongjun Hong, Miri Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	skin aging intrinsic aging photoaging molecular mechanisms Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d6d64040da334848a936179eac10cbd0
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spelling	oai:doaj.org-article:d6d64040da334848a936179eac10cbd02021-11-25T17:57:10ZStructural and Functional Changes and Possible Molecular Mechanisms in Aged Skin10.3390/ijms2222124891422-00671661-6596https://doaj.org/article/d6d64040da334848a936179eac10cbd02021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12489https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Skin aging is a complex process influenced by intrinsic and extrinsic factors. Together, these factors affect the structure and function of the epidermis and dermis. Histologically, aging skin typically shows epidermal atrophy due to decreased cell numbers. The dermis of aged skin shows decreased numbers of mast cells and fibroblasts. Fibroblast senescence contributes to skin aging by secreting a senescence-associated secretory phenotype, which decreases proliferation by impairing the release of essential growth factors and enhancing degradation of the extracellular matrix through activation of matrix metalloproteinases (MMPs). Several molecular mechanisms affect skin aging including telomere shortening, oxidative stress and MMP, cytokines, autophagic control, microRNAs, and the microbiome. Accumulating evidence on the molecular mechanisms of skin aging has provided clinicians with a wide range of therapeutic targets for treating aging skin.Hyunji LeeYongjun HongMiri KimMDPI AGarticleskin agingintrinsic agingphotoagingmolecular mechanismsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12489, p 12489 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	skin aging intrinsic aging photoaging molecular mechanisms Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	skin aging intrinsic aging photoaging molecular mechanisms Biology (General) QH301-705.5 Chemistry QD1-999 Hyunji Lee Yongjun Hong Miri Kim Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin
description	Skin aging is a complex process influenced by intrinsic and extrinsic factors. Together, these factors affect the structure and function of the epidermis and dermis. Histologically, aging skin typically shows epidermal atrophy due to decreased cell numbers. The dermis of aged skin shows decreased numbers of mast cells and fibroblasts. Fibroblast senescence contributes to skin aging by secreting a senescence-associated secretory phenotype, which decreases proliferation by impairing the release of essential growth factors and enhancing degradation of the extracellular matrix through activation of matrix metalloproteinases (MMPs). Several molecular mechanisms affect skin aging including telomere shortening, oxidative stress and MMP, cytokines, autophagic control, microRNAs, and the microbiome. Accumulating evidence on the molecular mechanisms of skin aging has provided clinicians with a wide range of therapeutic targets for treating aging skin.
format	article
author	Hyunji Lee Yongjun Hong Miri Kim
author_facet	Hyunji Lee Yongjun Hong Miri Kim
author_sort	Hyunji Lee
title	Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin
title_short	Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin
title_full	Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin
title_fullStr	Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin
title_full_unstemmed	Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin
title_sort	structural and functional changes and possible molecular mechanisms in aged skin
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d6d64040da334848a936179eac10cbd0
work_keys_str_mv	AT hyunjilee structuralandfunctionalchangesandpossiblemolecularmechanismsinagedskin AT yongjunhong structuralandfunctionalchangesandpossiblemolecularmechanismsinagedskin AT mirikim structuralandfunctionalchangesandpossiblemolecularmechanismsinagedskin
_version_	1718411834591019008

Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin

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