Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model.

Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model.

<h4>Background</h4>Current gene- and cell-based therapies have significant limitations which impede widespread clinical application. Taking diabetes mellitus as a paradigm, we have sought to overcome these limitations by ex vivo electrotransfer of a nonviral insulin expression vector int...

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Auteurs principaux: Nelson K F Chen, Jen San Wong, Irene H C Kee, Siang Hui Lai, Choon Hua Thng, Wai Har Ng, Robert T H Ng, Soo Yong Tan, Shu Yen Lee, Mark E H Tan, Jaichandran Sivalingam, Pierce K H Chow, Oi Lian Kon
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2008
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/d6d641e5934441eda05c41c85f05a2af
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https://doaj.org/article/d6d641e5934441eda05c41c85f05a2af

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