Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model.
<h4>Background</h4>Current gene- and cell-based therapies have significant limitations which impede widespread clinical application. Taking diabetes mellitus as a paradigm, we have sought to overcome these limitations by ex vivo electrotransfer of a nonviral insulin expression vector int...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Public Library of Science (PLoS)
2008
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| Subjects: | |
| Online Access: | https://doaj.org/article/d6d641e5934441eda05c41c85f05a2af |
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