Correlation between circulating interleukin-18 level and systemic lupus erythematosus: a meta-analysis

Abstract This study is a meta-analysis aimed at pooling reported data and clarifying the association between circulating level of interleukin-18 and systemic lupus erythematosus (SLE). We searched medical databases including Medline/Pubmed, Embase, Scopus, The Cochrane Library, and Web of Science th...

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Autores principales:	Mengmeng Xiang, Yang Feng, Yilun Wang, Jie Wang, Zhixiong Zhang, Jun Liang, Jinhua Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d6d83f7deeaa4c52ae8615f6b5cb4214
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spelling	oai:doaj.org-article:d6d83f7deeaa4c52ae8615f6b5cb42142021-12-02T13:19:30ZCorrelation between circulating interleukin-18 level and systemic lupus erythematosus: a meta-analysis10.1038/s41598-021-84170-42045-2322https://doaj.org/article/d6d83f7deeaa4c52ae8615f6b5cb42142021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84170-4https://doaj.org/toc/2045-2322Abstract This study is a meta-analysis aimed at pooling reported data and clarifying the association between circulating level of interleukin-18 and systemic lupus erythematosus (SLE). We searched medical databases including Medline/Pubmed, Embase, Scopus, The Cochrane Library, and Web of Science thoroughly to obtain all related articles published before July 15th, 2020. We pooled computed standardized mean difference (SMD) and its 95% confidence interval using STATA 13.0 and exhibited in the form of forest graph. Meta-regression and subgroup analysis were also performed to explore the source of heterogeneity. Publication bias was first evaluated by the symmetry of the funnel plot and then Egger’s linear regression test. Thirty eligible studies from eighteen regions were finally included and the relevant data from these studies were pooled. The analysis results displayed that SLE patients showed a significantly higher level of circulating IL-18 level in comparison with healthy controls (SMD = 1.56, 95% CI [1.20–1.93]; I2 = 94.9%, p < 0.01). The conclusion was equally applicable in subgroups divided based on sample type, mean age, disease duration, and testing method. Patients with SLEDAI score higher than five, or who were Asian, White, Arab, or mixed ethnicity had an elevated level of IL-18, while the others didn’t. This meta-analysis has elucidated that compared with healthy people, the circulating level of IL-18 is considerably higher in SLE patients, which indicates the underlying role of IL-18 in SLE pathogenesis.Mengmeng XiangYang FengYilun WangJie WangZhixiong ZhangJun LiangJinhua XuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mengmeng Xiang Yang Feng Yilun Wang Jie Wang Zhixiong Zhang Jun Liang Jinhua Xu Correlation between circulating interleukin-18 level and systemic lupus erythematosus: a meta-analysis
description	Abstract This study is a meta-analysis aimed at pooling reported data and clarifying the association between circulating level of interleukin-18 and systemic lupus erythematosus (SLE). We searched medical databases including Medline/Pubmed, Embase, Scopus, The Cochrane Library, and Web of Science thoroughly to obtain all related articles published before July 15th, 2020. We pooled computed standardized mean difference (SMD) and its 95% confidence interval using STATA 13.0 and exhibited in the form of forest graph. Meta-regression and subgroup analysis were also performed to explore the source of heterogeneity. Publication bias was first evaluated by the symmetry of the funnel plot and then Egger’s linear regression test. Thirty eligible studies from eighteen regions were finally included and the relevant data from these studies were pooled. The analysis results displayed that SLE patients showed a significantly higher level of circulating IL-18 level in comparison with healthy controls (SMD = 1.56, 95% CI [1.20–1.93]; I2 = 94.9%, p < 0.01). The conclusion was equally applicable in subgroups divided based on sample type, mean age, disease duration, and testing method. Patients with SLEDAI score higher than five, or who were Asian, White, Arab, or mixed ethnicity had an elevated level of IL-18, while the others didn’t. This meta-analysis has elucidated that compared with healthy people, the circulating level of IL-18 is considerably higher in SLE patients, which indicates the underlying role of IL-18 in SLE pathogenesis.
format	article
author	Mengmeng Xiang Yang Feng Yilun Wang Jie Wang Zhixiong Zhang Jun Liang Jinhua Xu
author_facet	Mengmeng Xiang Yang Feng Yilun Wang Jie Wang Zhixiong Zhang Jun Liang Jinhua Xu
author_sort	Mengmeng Xiang
title	Correlation between circulating interleukin-18 level and systemic lupus erythematosus: a meta-analysis
title_short	Correlation between circulating interleukin-18 level and systemic lupus erythematosus: a meta-analysis
title_full	Correlation between circulating interleukin-18 level and systemic lupus erythematosus: a meta-analysis
title_fullStr	Correlation between circulating interleukin-18 level and systemic lupus erythematosus: a meta-analysis
title_full_unstemmed	Correlation between circulating interleukin-18 level and systemic lupus erythematosus: a meta-analysis
title_sort	correlation between circulating interleukin-18 level and systemic lupus erythematosus: a meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d6d83f7deeaa4c52ae8615f6b5cb4214
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Correlation between circulating interleukin-18 level and systemic lupus erythematosus: a meta-analysis

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