The effects of antibiotic exposure on asthma in children with atopic dermatitis

Abstract Early-life antibiotic use is associated with allergic diseases. The risk factors for the progression from atopic dermatitis (AD) to asthma or allergic rhinitis are still unknown. We aimed to investigate the association between exposure to different antibiotics and the risk of new-onset asth...

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Autores principales:	I-Lun Chen, Ming-Kai Tsai, Hao-Wei Chung, Hui-Min Hsieh, Yu-Ting Huang, Yi-Ching Lin, Chih-Hsing Hung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d6d95cd7e8b142108a8f5899f6590a95
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spelling	oai:doaj.org-article:d6d95cd7e8b142108a8f5899f6590a952021-12-02T13:39:34ZThe effects of antibiotic exposure on asthma in children with atopic dermatitis10.1038/s41598-021-87981-72045-2322https://doaj.org/article/d6d95cd7e8b142108a8f5899f6590a952021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87981-7https://doaj.org/toc/2045-2322Abstract Early-life antibiotic use is associated with allergic diseases. The risk factors for the progression from atopic dermatitis (AD) to asthma or allergic rhinitis are still unknown. We aimed to investigate the association between exposure to different antibiotics and the risk of new-onset asthma in children with AD. By using the Longitudinal Health Insurance Database 2005, we selected AD patients less than 6 years old identified by ICD-9-CM code 691.8. The case group was defined as those having new-onset asthma, and the control group was defined as those without an asthma history. Information on antibiotic exposure in the 5 years prior to the index date was collected from drug prescription records. We estimated the adjusted odds ratio by using conditional logistic regression, adjusted for age, sex, index year, other potential risk factors and antibiotics. Antibiotic exposure was associated with the development of asthma in patients with AD (aOR = 3.68, 95% CI 2.13–6.36), particularly for patients less than 5 years old (aOR = 4.14, 95% CI 2.24–7.64) (p for trend < 0.001), even though lower cumulative antibiotic defined daily doses (DDDs) were associated with new-onset asthma occurrence. Antibiotic exposure, especially macrolide exposure, is associated with an increased risk of asthma in patients with AD.I-Lun ChenMing-Kai TsaiHao-Wei ChungHui-Min HsiehYu-Ting HuangYi-Ching LinChih-Hsing HungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q I-Lun Chen Ming-Kai Tsai Hao-Wei Chung Hui-Min Hsieh Yu-Ting Huang Yi-Ching Lin Chih-Hsing Hung The effects of antibiotic exposure on asthma in children with atopic dermatitis
description	Abstract Early-life antibiotic use is associated with allergic diseases. The risk factors for the progression from atopic dermatitis (AD) to asthma or allergic rhinitis are still unknown. We aimed to investigate the association between exposure to different antibiotics and the risk of new-onset asthma in children with AD. By using the Longitudinal Health Insurance Database 2005, we selected AD patients less than 6 years old identified by ICD-9-CM code 691.8. The case group was defined as those having new-onset asthma, and the control group was defined as those without an asthma history. Information on antibiotic exposure in the 5 years prior to the index date was collected from drug prescription records. We estimated the adjusted odds ratio by using conditional logistic regression, adjusted for age, sex, index year, other potential risk factors and antibiotics. Antibiotic exposure was associated with the development of asthma in patients with AD (aOR = 3.68, 95% CI 2.13–6.36), particularly for patients less than 5 years old (aOR = 4.14, 95% CI 2.24–7.64) (p for trend < 0.001), even though lower cumulative antibiotic defined daily doses (DDDs) were associated with new-onset asthma occurrence. Antibiotic exposure, especially macrolide exposure, is associated with an increased risk of asthma in patients with AD.
format	article
author	I-Lun Chen Ming-Kai Tsai Hao-Wei Chung Hui-Min Hsieh Yu-Ting Huang Yi-Ching Lin Chih-Hsing Hung
author_facet	I-Lun Chen Ming-Kai Tsai Hao-Wei Chung Hui-Min Hsieh Yu-Ting Huang Yi-Ching Lin Chih-Hsing Hung
author_sort	I-Lun Chen
title	The effects of antibiotic exposure on asthma in children with atopic dermatitis
title_short	The effects of antibiotic exposure on asthma in children with atopic dermatitis
title_full	The effects of antibiotic exposure on asthma in children with atopic dermatitis
title_fullStr	The effects of antibiotic exposure on asthma in children with atopic dermatitis
title_full_unstemmed	The effects of antibiotic exposure on asthma in children with atopic dermatitis
title_sort	effects of antibiotic exposure on asthma in children with atopic dermatitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d6d95cd7e8b142108a8f5899f6590a95
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The effects of antibiotic exposure on asthma in children with atopic dermatitis

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