Topical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocream

Muthanna F Abdulkarim1*, Ghassan Z Abdullah1*, Mallikarjun Chitneni2, Ibrahim M Salman1, Omar Z Ameer1, Mun F Yam1,3, Elrashid S Mahdi1, Munavvar A Sattar1, Mahiran Basri4, Azmin M Noor11School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia; 2School of Pharmacy and Health Sc...

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Autores principales:	Muthanna F Abdulkarim, Ghassan Z Abdullah, Mallikarjun Chitneni, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d6dab4b6df38498dad49437c5592e568
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spelling	oai:doaj.org-article:d6dab4b6df38498dad49437c5592e5682021-12-02T02:46:36ZTopical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocream1176-91141178-2013https://doaj.org/article/d6dab4b6df38498dad49437c5592e5682010-11-01T00:00:00Zhttp://www.dovepress.com/topical-piroxicam-in-vitro-release-and-in-vivo-anti-inflammatory-and-a-a5596https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Muthanna F Abdulkarim1, Ghassan Z Abdullah1, Mallikarjun Chitneni2, Ibrahim M Salman1, Omar Z Ameer1, Mun F Yam1,3, Elrashid S Mahdi1, Munavvar A Sattar1, Mahiran Basri4, Azmin M Noor11School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia; 2School of Pharmacy and Health Sciences, International Medical University, Kuala Lumpur, Malaysia; 3Faculty of Medicine and Health Sciences, 4Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia; *The First and Second Authors have Contributed Equally to this WorkIntroduction: During recent years, there has been growing interest in use of topical vehicle systems to assist in drug permeation through the skin. Drugs of interest are usually those that are problematic when given orally, such as piroxicam, a highly effective anti-inflammatory, antipyretic, and analgesic, but with the adverse effect of causing gastrointestinal ulcers. The present study investigated the in vitro and in vivo pharmacodynamic activity of a newly synthesized palm oil esters (POEs)-based nanocream containing piroxicam for topical delivery.Methods: A ratio of 25:37:38 of POEs: external phase: surfactants (Tween 80:Span 20, in a ratio 80:20), respectively was selected as the basic composition for the production of a nanocream with ideal properties. Various nanocreams were prepared using phosphate-buffered saline as the external phase at three different pH values. The abilities of these formulae to deliver piroxicam were assessed in vitro using a Franz diffusion cell fitted with a cellulose acetate membrane and full thickness rat skin. These formulae were also evaluated in vivo by comparing their anti-inflammatory and analgesic activities with those of the currently marketed gel.Results: After eight hours, nearly 100% of drug was transferred through the artificial membrane from the prepared formula F3 (phosphate-buffered saline at pH 7.4 as the external phase) and the marketed gel. The steady-state flux through rat skin of all formulae tested was higher than that of the marketed gel. Pharmacodynamically, nanocream formula F3 exhibited the highest anti-inflammatory and analgesic effects as compared with the other formulae.Conclusion: The nanocream containing the newly synthesized POEs was successful for transdermal delivery of piroxicam.Keywords: piroxicam, nanocream, analgesic, anti-inflammatory, skin permeation Muthanna F AbdulkarimGhassan Z AbdullahMallikarjun Chitneniet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 915-924 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Muthanna F Abdulkarim Ghassan Z Abdullah Mallikarjun Chitneni et al Topical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocream
description	Muthanna F Abdulkarim1, Ghassan Z Abdullah1, Mallikarjun Chitneni2, Ibrahim M Salman1, Omar Z Ameer1, Mun F Yam1,3, Elrashid S Mahdi1, Munavvar A Sattar1, Mahiran Basri4, Azmin M Noor11School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia; 2School of Pharmacy and Health Sciences, International Medical University, Kuala Lumpur, Malaysia; 3Faculty of Medicine and Health Sciences, 4Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia; *The First and Second Authors have Contributed Equally to this WorkIntroduction: During recent years, there has been growing interest in use of topical vehicle systems to assist in drug permeation through the skin. Drugs of interest are usually those that are problematic when given orally, such as piroxicam, a highly effective anti-inflammatory, antipyretic, and analgesic, but with the adverse effect of causing gastrointestinal ulcers. The present study investigated the in vitro and in vivo pharmacodynamic activity of a newly synthesized palm oil esters (POEs)-based nanocream containing piroxicam for topical delivery.Methods: A ratio of 25:37:38 of POEs: external phase: surfactants (Tween 80:Span 20, in a ratio 80:20), respectively was selected as the basic composition for the production of a nanocream with ideal properties. Various nanocreams were prepared using phosphate-buffered saline as the external phase at three different pH values. The abilities of these formulae to deliver piroxicam were assessed in vitro using a Franz diffusion cell fitted with a cellulose acetate membrane and full thickness rat skin. These formulae were also evaluated in vivo by comparing their anti-inflammatory and analgesic activities with those of the currently marketed gel.Results: After eight hours, nearly 100% of drug was transferred through the artificial membrane from the prepared formula F3 (phosphate-buffered saline at pH 7.4 as the external phase) and the marketed gel. The steady-state flux through rat skin of all formulae tested was higher than that of the marketed gel. Pharmacodynamically, nanocream formula F3 exhibited the highest anti-inflammatory and analgesic effects as compared with the other formulae.Conclusion: The nanocream containing the newly synthesized POEs was successful for transdermal delivery of piroxicam.Keywords: piroxicam, nanocream, analgesic, anti-inflammatory, skin permeation
format	article
author	Muthanna F Abdulkarim Ghassan Z Abdullah Mallikarjun Chitneni et al
author_facet	Muthanna F Abdulkarim Ghassan Z Abdullah Mallikarjun Chitneni et al
author_sort	Muthanna F Abdulkarim
title	Topical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocream
title_short	Topical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocream
title_full	Topical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocream
title_fullStr	Topical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocream
title_full_unstemmed	Topical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocream
title_sort	topical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocream
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/d6dab4b6df38498dad49437c5592e568
work_keys_str_mv	AT muthannafabdulkarim topicalpiroxicaminvitroreleaseandinvivoantiinflammatoryandanalgesiceffectsfrompalmoilestersbasednanocream AT ghassanzabdullah topicalpiroxicaminvitroreleaseandinvivoantiinflammatoryandanalgesiceffectsfrompalmoilestersbasednanocream AT mallikarjunchitneni topicalpiroxicaminvitroreleaseandinvivoantiinflammatoryandanalgesiceffectsfrompalmoilestersbasednanocream AT etal topicalpiroxicaminvitroreleaseandinvivoantiinflammatoryandanalgesiceffectsfrompalmoilestersbasednanocream
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Topical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocream

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