CLINICAL EFFECTS OF MESENCHYMAL STROMAL CELLS IN LYMPHOMA PATIENTS WITH AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION

The clinical and laboratory effects of bone-marrow derived mesenchymal stromal cells (MSC) in patients with malignant lymphomas following autologous hematopoietic stem cell transplantation (auto-HSCT) have been investigated. Co-transplantation of MSC in average dose of 0,178 106/kg was conducted in...

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Autores principales:	E. V. Batorov, E. Ya. Shevela, I. V. Kryuchkova, D. S. Baranova, V. V. Sergeevicheva, S. A. Sizikova, G. Yu. Ushakova, A. V. Gilevich, A. A. Ostanin, E. R. Chernykh
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	mesenchymal stromal cells hematopoietic stem cells transplantation Science Q
Acceso en línea:	https://doaj.org/article/d6e0ecf3c6e24f6696a496651fbf816e
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spelling	oai:doaj.org-article:d6e0ecf3c6e24f6696a496651fbf816e2021-11-23T06:14:19ZCLINICAL EFFECTS OF MESENCHYMAL STROMAL CELLS IN LYMPHOMA PATIENTS WITH AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION2541-94202587-9596https://doaj.org/article/d6e0ecf3c6e24f6696a496651fbf816e2012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/880https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The clinical and laboratory effects of bone-marrow derived mesenchymal stromal cells (MSC) in patients with malignant lymphomas following autologous hematopoietic stem cell transplantation (auto-HSCT) have been investigated. Co-transplantation of MSC in average dose of 0,178 106/kg was conducted in 74 patients with auto-HSCT. The control group included 83 patients eligible for standard HSCT. We revealed the decreasing of the period of neutropenia and thrombocytopenia when hematopoietic stem cells were co-transplanted with low doses ex vivo expanded autologous MSC. Patients with MSC co-transplantation were differed by more effective early lymphocyte recovery. At the same time MSC co-transplantation did not increase the incidence of infectious complications and cases of renal and. hepatic toxicity. Patients with MSC co-transplantation did not differ from opposite group by 5-year overall survival, but were characterized by significantly better progression-free survival.E. V. BatorovE. Ya. ShevelaI. V. KryuchkovaD. S. BaranovaV. V. SergeevichevaS. A. SizikovaG. Yu. UshakovaA. V. GilevichA. A. OstaninE. R. ChernykhScientific Сentre for Family Health and Human Reproduction Problemsarticlemesenchymal stromal cellshematopoietic stem cells transplantationScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 33-37 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	mesenchymal stromal cells hematopoietic stem cells transplantation Science Q
spellingShingle	mesenchymal stromal cells hematopoietic stem cells transplantation Science Q E. V. Batorov E. Ya. Shevela I. V. Kryuchkova D. S. Baranova V. V. Sergeevicheva S. A. Sizikova G. Yu. Ushakova A. V. Gilevich A. A. Ostanin E. R. Chernykh CLINICAL EFFECTS OF MESENCHYMAL STROMAL CELLS IN LYMPHOMA PATIENTS WITH AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION
description	The clinical and laboratory effects of bone-marrow derived mesenchymal stromal cells (MSC) in patients with malignant lymphomas following autologous hematopoietic stem cell transplantation (auto-HSCT) have been investigated. Co-transplantation of MSC in average dose of 0,178 106/kg was conducted in 74 patients with auto-HSCT. The control group included 83 patients eligible for standard HSCT. We revealed the decreasing of the period of neutropenia and thrombocytopenia when hematopoietic stem cells were co-transplanted with low doses ex vivo expanded autologous MSC. Patients with MSC co-transplantation were differed by more effective early lymphocyte recovery. At the same time MSC co-transplantation did not increase the incidence of infectious complications and cases of renal and. hepatic toxicity. Patients with MSC co-transplantation did not differ from opposite group by 5-year overall survival, but were characterized by significantly better progression-free survival.
format	article
author	E. V. Batorov E. Ya. Shevela I. V. Kryuchkova D. S. Baranova V. V. Sergeevicheva S. A. Sizikova G. Yu. Ushakova A. V. Gilevich A. A. Ostanin E. R. Chernykh
author_facet	E. V. Batorov E. Ya. Shevela I. V. Kryuchkova D. S. Baranova V. V. Sergeevicheva S. A. Sizikova G. Yu. Ushakova A. V. Gilevich A. A. Ostanin E. R. Chernykh
author_sort	E. V. Batorov
title	CLINICAL EFFECTS OF MESENCHYMAL STROMAL CELLS IN LYMPHOMA PATIENTS WITH AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION
title_short	CLINICAL EFFECTS OF MESENCHYMAL STROMAL CELLS IN LYMPHOMA PATIENTS WITH AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION
title_full	CLINICAL EFFECTS OF MESENCHYMAL STROMAL CELLS IN LYMPHOMA PATIENTS WITH AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION
title_fullStr	CLINICAL EFFECTS OF MESENCHYMAL STROMAL CELLS IN LYMPHOMA PATIENTS WITH AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION
title_full_unstemmed	CLINICAL EFFECTS OF MESENCHYMAL STROMAL CELLS IN LYMPHOMA PATIENTS WITH AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION
title_sort	clinical effects of mesenchymal stromal cells in lymphoma patients with autologous hematopoietic stem cell transplantation
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/d6e0ecf3c6e24f6696a496651fbf816e
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CLINICAL EFFECTS OF MESENCHYMAL STROMAL CELLS IN LYMPHOMA PATIENTS WITH AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION

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