Association of maternal obesity with fetal and neonatal death: Evidence from South and South-East Asian countries.

<h4>Background</h4>Obesity prevalence is increasing in many countries in the world, including Asia. Maternal obesity is highly associated with fetal and neonatal deaths. This study investigated whether maternal obesity is a risk factor of fetal death (measured in terms of miscarriage and...

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Autores principales:	Rezwanul Haque, Syed Afroz Keramat, Syed Mahbubur Rahman, Maimun Ur Rashid Mustafa, Khorshed Alam
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d6e1f8680e874745aa443087636c6f05
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spelling	oai:doaj.org-article:d6e1f8680e874745aa443087636c6f052021-12-02T20:08:36ZAssociation of maternal obesity with fetal and neonatal death: Evidence from South and South-East Asian countries.1932-620310.1371/journal.pone.0256725https://doaj.org/article/d6e1f8680e874745aa443087636c6f052021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256725https://doaj.org/toc/1932-6203<h4>Background</h4>Obesity prevalence is increasing in many countries in the world, including Asia. Maternal obesity is highly associated with fetal and neonatal deaths. This study investigated whether maternal obesity is a risk factor of fetal death (measured in terms of miscarriage and stillbirth) and neonatal mortality in South and South-East Asian countries.<h4>Methods</h4>This cross-sectional study pooled the most recent Demographic and Health Surveys (DHS) from eight South and South-East Asian countries (2014-2018). Multivariate logistic regression was deployed to check the relationships between maternal obesity with fetal and neonatal deaths. Finally, multilevel logistic regression model was employed since the DHS data has a hierarchical structure.<h4>Results</h4>The pooled logistic regression model illustrated that maternal obesity is associated with higher odds of miscarriage (adjusted odds ratio [aOR]: 1.26, 95% CI: 1.20-1.33) and stillbirths (aOR: 1.46, 95% CI: 1.27-1.67) after adjustment of confounders. Children of obese mothers were at 1.18 (aOR: 1.18, 95% CI: 1.08-1.28) times greater risk of dying during the early neonatal period than mothers with a healthy weight. However, whether maternal obesity is statistically a significant risk factor for the offspring's late neonatal deaths was not confirmed. The significant association between maternal obesity with miscarriage, stillbirth and early neonatal mortality was further confirmed by multilevel logistic regression results.<h4>Conclusion</h4>Maternal obesity in South and South-East Asian countries is associated with a greater risk of fetal and early neonatal deaths. This finding has substantial public health implications. Strategies to prevent and reduce obesity should be developed before planning pregnancy to reduce the fetal and neonatal death burden. Obese women need to deliver at the institutional facility centre that can offer obstetrics and early neonatal care.Rezwanul HaqueSyed Afroz KeramatSyed Mahbubur RahmanMaimun Ur Rashid MustafaKhorshed AlamPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0256725 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rezwanul Haque Syed Afroz Keramat Syed Mahbubur Rahman Maimun Ur Rashid Mustafa Khorshed Alam Association of maternal obesity with fetal and neonatal death: Evidence from South and South-East Asian countries.
description	<h4>Background</h4>Obesity prevalence is increasing in many countries in the world, including Asia. Maternal obesity is highly associated with fetal and neonatal deaths. This study investigated whether maternal obesity is a risk factor of fetal death (measured in terms of miscarriage and stillbirth) and neonatal mortality in South and South-East Asian countries.<h4>Methods</h4>This cross-sectional study pooled the most recent Demographic and Health Surveys (DHS) from eight South and South-East Asian countries (2014-2018). Multivariate logistic regression was deployed to check the relationships between maternal obesity with fetal and neonatal deaths. Finally, multilevel logistic regression model was employed since the DHS data has a hierarchical structure.<h4>Results</h4>The pooled logistic regression model illustrated that maternal obesity is associated with higher odds of miscarriage (adjusted odds ratio [aOR]: 1.26, 95% CI: 1.20-1.33) and stillbirths (aOR: 1.46, 95% CI: 1.27-1.67) after adjustment of confounders. Children of obese mothers were at 1.18 (aOR: 1.18, 95% CI: 1.08-1.28) times greater risk of dying during the early neonatal period than mothers with a healthy weight. However, whether maternal obesity is statistically a significant risk factor for the offspring's late neonatal deaths was not confirmed. The significant association between maternal obesity with miscarriage, stillbirth and early neonatal mortality was further confirmed by multilevel logistic regression results.<h4>Conclusion</h4>Maternal obesity in South and South-East Asian countries is associated with a greater risk of fetal and early neonatal deaths. This finding has substantial public health implications. Strategies to prevent and reduce obesity should be developed before planning pregnancy to reduce the fetal and neonatal death burden. Obese women need to deliver at the institutional facility centre that can offer obstetrics and early neonatal care.
format	article
author	Rezwanul Haque Syed Afroz Keramat Syed Mahbubur Rahman Maimun Ur Rashid Mustafa Khorshed Alam
author_facet	Rezwanul Haque Syed Afroz Keramat Syed Mahbubur Rahman Maimun Ur Rashid Mustafa Khorshed Alam
author_sort	Rezwanul Haque
title	Association of maternal obesity with fetal and neonatal death: Evidence from South and South-East Asian countries.
title_short	Association of maternal obesity with fetal and neonatal death: Evidence from South and South-East Asian countries.
title_full	Association of maternal obesity with fetal and neonatal death: Evidence from South and South-East Asian countries.
title_fullStr	Association of maternal obesity with fetal and neonatal death: Evidence from South and South-East Asian countries.
title_full_unstemmed	Association of maternal obesity with fetal and neonatal death: Evidence from South and South-East Asian countries.
title_sort	association of maternal obesity with fetal and neonatal death: evidence from south and south-east asian countries.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d6e1f8680e874745aa443087636c6f05
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Association of maternal obesity with fetal and neonatal death: Evidence from South and South-East Asian countries.

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