A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress

Reactive oxygen species (ROS) are metabolic by-products which in excess can be toxic for hematopoietic stem and progenitor cells (HSPCs). Here the authors show that toxic ROS are transferred by expanding HSPCs to the zebrafish developmental niche via connexin Cx41.8, where Ifi30 promotes their detox...

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Autores principales:	Pietro Cacialli, Christopher B. Mahony, Tim Petzold, Patrizia Bordignon, Anne-Laure Rougemont, Julien Y. Bertrand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d6e3a9bccebb4f0c9f856c6cbade5db4
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spelling	oai:doaj.org-article:d6e3a9bccebb4f0c9f856c6cbade5db42021-12-02T16:26:32ZA connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress10.1038/s41467-021-24831-02041-1723https://doaj.org/article/d6e3a9bccebb4f0c9f856c6cbade5db42021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24831-0https://doaj.org/toc/2041-1723Reactive oxygen species (ROS) are metabolic by-products which in excess can be toxic for hematopoietic stem and progenitor cells (HSPCs). Here the authors show that toxic ROS are transferred by expanding HSPCs to the zebrafish developmental niche via connexin Cx41.8, where Ifi30 promotes their detoxification.Pietro CacialliChristopher B. MahonyTim PetzoldPatrizia BordignonAnne-Laure RougemontJulien Y. BertrandNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pietro Cacialli Christopher B. Mahony Tim Petzold Patrizia Bordignon Anne-Laure Rougemont Julien Y. Bertrand A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress
description	Reactive oxygen species (ROS) are metabolic by-products which in excess can be toxic for hematopoietic stem and progenitor cells (HSPCs). Here the authors show that toxic ROS are transferred by expanding HSPCs to the zebrafish developmental niche via connexin Cx41.8, where Ifi30 promotes their detoxification.
format	article
author	Pietro Cacialli Christopher B. Mahony Tim Petzold Patrizia Bordignon Anne-Laure Rougemont Julien Y. Bertrand
author_facet	Pietro Cacialli Christopher B. Mahony Tim Petzold Patrizia Bordignon Anne-Laure Rougemont Julien Y. Bertrand
author_sort	Pietro Cacialli
title	A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress
title_short	A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress
title_full	A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress
title_fullStr	A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress
title_full_unstemmed	A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress
title_sort	connexin/ifi30 pathway bridges hscs with their niche to dampen oxidative stress
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d6e3a9bccebb4f0c9f856c6cbade5db4
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A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress

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