Mechanistic insight into the interaction of gastrointestinal mucus with oral diblock copolymers synthesized via ATRP method

Jiao Liu,1,* Jie Cao,1,* Jianhua Cao,2 Shangcong Han,1 Yan Liang,1 Mingfeng Bai,3 Yong Sun1 1Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, China; 2Department of Pharmacy, Qingdao No 3 Hospital, Qingdao, China; 3Department of Radiology and Radiological Sciences, Insti...

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Autores principales:	Liu J, Cao J, Cao JH, Han SC, Liang Y, Bai MF, Sun Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Gastrointestinal mucus Oral drug delivery system ATRP Diblock copolymers Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d6e4bc6dbf9d401ea877f3d4bb426088
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spelling	oai:doaj.org-article:d6e4bc6dbf9d401ea877f3d4bb4260882021-12-02T04:12:57ZMechanistic insight into the interaction of gastrointestinal mucus with oral diblock copolymers synthesized via ATRP method1178-2013https://doaj.org/article/d6e4bc6dbf9d401ea877f3d4bb4260882018-05-01T00:00:00Zhttps://www.dovepress.com/mechanistic-insight-into-the-interaction-of-gastrointestinal-mucus-wit-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jiao Liu,1,* Jie Cao,1,* Jianhua Cao,2 Shangcong Han,1 Yan Liang,1 Mingfeng Bai,3 Yong Sun1 1Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, China; 2Department of Pharmacy, Qingdao No 3 Hospital, Qingdao, China; 3Department of Radiology and Radiological Sciences, Institute of Imaging Sciences, Vanderbilt University Medical Center, Nashville, TN, USA *These authors contributed equally to this work Introduction: Nanoparticles are increasingly used as drug carriers for oral administration. The delivery of drug molecules is largely dependent on the interaction of nanocarriers and gastrointestinal (GI) mucus, a critical barrier that regulates drug absorption. It is therefore important to understand the effects of physical and chemical properties of nanocarriers on the interaction with GI mucus. Unfortunately, most of the nanoparticles are unable to be prepared with satisfactory structural monodispersity to comprehensively investigate the interaction. With controlled size, shape, and surface chemistry, copolymers are ideal candidates for such purpose. Materials and methods: We synthesized a series of diblock copolymers via the atom transfer radical polymerization method and investigated the GI mucus permeability in vitro and in vivo. Results: Our results indicated that uncharged and hydrophobic copolymers exhibited enhanced GI absorption. Conclusion: These results provide insights into developing optimal nanocarriers for oral administration. Keywords: absorption barriers, oral drug delivery system, ATRP, nanoparticlesLiu JCao JCao JHHan SCLiang YBai MFSun YDove Medical PressarticleGastrointestinal mucusOral drug delivery systemATRPDiblock copolymersMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 2839-2856 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gastrointestinal mucus Oral drug delivery system ATRP Diblock copolymers Medicine (General) R5-920
spellingShingle	Gastrointestinal mucus Oral drug delivery system ATRP Diblock copolymers Medicine (General) R5-920 Liu J Cao J Cao JH Han SC Liang Y Bai MF Sun Y Mechanistic insight into the interaction of gastrointestinal mucus with oral diblock copolymers synthesized via ATRP method
description	Jiao Liu,1,* Jie Cao,1,* Jianhua Cao,2 Shangcong Han,1 Yan Liang,1 Mingfeng Bai,3 Yong Sun1 1Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, China; 2Department of Pharmacy, Qingdao No 3 Hospital, Qingdao, China; 3Department of Radiology and Radiological Sciences, Institute of Imaging Sciences, Vanderbilt University Medical Center, Nashville, TN, USA *These authors contributed equally to this work Introduction: Nanoparticles are increasingly used as drug carriers for oral administration. The delivery of drug molecules is largely dependent on the interaction of nanocarriers and gastrointestinal (GI) mucus, a critical barrier that regulates drug absorption. It is therefore important to understand the effects of physical and chemical properties of nanocarriers on the interaction with GI mucus. Unfortunately, most of the nanoparticles are unable to be prepared with satisfactory structural monodispersity to comprehensively investigate the interaction. With controlled size, shape, and surface chemistry, copolymers are ideal candidates for such purpose. Materials and methods: We synthesized a series of diblock copolymers via the atom transfer radical polymerization method and investigated the GI mucus permeability in vitro and in vivo. Results: Our results indicated that uncharged and hydrophobic copolymers exhibited enhanced GI absorption. Conclusion: These results provide insights into developing optimal nanocarriers for oral administration. Keywords: absorption barriers, oral drug delivery system, ATRP, nanoparticles
format	article
author	Liu J Cao J Cao JH Han SC Liang Y Bai MF Sun Y
author_facet	Liu J Cao J Cao JH Han SC Liang Y Bai MF Sun Y
author_sort	Liu J
title	Mechanistic insight into the interaction of gastrointestinal mucus with oral diblock copolymers synthesized via ATRP method
title_short	Mechanistic insight into the interaction of gastrointestinal mucus with oral diblock copolymers synthesized via ATRP method
title_full	Mechanistic insight into the interaction of gastrointestinal mucus with oral diblock copolymers synthesized via ATRP method
title_fullStr	Mechanistic insight into the interaction of gastrointestinal mucus with oral diblock copolymers synthesized via ATRP method
title_full_unstemmed	Mechanistic insight into the interaction of gastrointestinal mucus with oral diblock copolymers synthesized via ATRP method
title_sort	mechanistic insight into the interaction of gastrointestinal mucus with oral diblock copolymers synthesized via atrp method
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/d6e4bc6dbf9d401ea877f3d4bb426088
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Mechanistic insight into the interaction of gastrointestinal mucus with oral diblock copolymers synthesized via ATRP method

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