Multifunctional nanocomposite based on halloysite nanotubes for efficient luminescent bioimaging and magnetic resonance imaging

Tao Zhou,1 Lei Jia,1 Yi-Feng Luo,2 Jun Xu,1 Ru-Hua Chen,2 Zhi-Jun Ge,2 Tie-Liang Ma,2 Hong Chen,2 Tao-Feng Zhu2 1Department of Physics and Chemistry, Henan Polytechnic University, Jiaozuo, Henan, 2The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, People’s Republic of...

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Autores principales:	Zhou T, Jia L, Luo YF, Xu J, Chen RH, Ge ZJ, Ma TL, Chen H, Zhu TF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	halloysite nanotube lanthanide complex iron oxide luminescence contrast agent Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d6e6e3ea301249d0b43f52aafb305718
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spelling	oai:doaj.org-article:d6e6e3ea301249d0b43f52aafb3057182021-12-02T07:13:44ZMultifunctional nanocomposite based on halloysite nanotubes for efficient luminescent bioimaging and magnetic resonance imaging1178-2013https://doaj.org/article/d6e6e3ea301249d0b43f52aafb3057182016-09-01T00:00:00Zhttps://www.dovepress.com/multifunctional-nanocomposite-based-on-halloysite-nanotubes-for-effici-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Tao Zhou,1 Lei Jia,1 Yi-Feng Luo,2 Jun Xu,1 Ru-Hua Chen,2 Zhi-Jun Ge,2 Tie-Liang Ma,2 Hong Chen,2 Tao-Feng Zhu2 1Department of Physics and Chemistry, Henan Polytechnic University, Jiaozuo, Henan, 2The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, People’s Republic of China Abstract: A novel multifunctional halloysite nanotube (HNT)-based Fe3O4@HNT-polyethyleneimine-Tip-Eu(dibenzoylmethane)3 nanocomposite (Fe-HNT-Eu NC) with both photoluminescent and magnetic properties was fabricated by a simple one-step hydrothermal process combined with the coupling grafting method, which exhibited high suspension stability and excellent photophysical behavior. The as-prepared multifunctional Fe-HNT-Eu NC was characterized using various techniques. The results of cell viability assay, cell morphological observation, and in vivo toxicity assay indicated that the NC exhibited excellent biocompatibility over the studied concentration range, suggesting that the obtained Fe-HNT-Eu NC was a suitable material for bioimaging and biological applications in human hepatic adenocarcinoma cells. Furthermore, the biocompatible Fe-HNT-Eu NC displayed superparamagnetic behavior with high saturation magnetization and also functioned as a magnetic resonance imaging (MRI) contrast agent in vitro and in vivo. The results of the MRI tests indicated that the Fe-HNT-Eu NC can significantly decrease the T2 signal intensity values of the normal liver tissue and thus make the boundary between the normal liver and transplanted cancer more distinct, thus effectively improving the diagnosis effect of cancers. Keywords: halloysite nanotube, lanthanide complex, iron oxide, luminescence, contrast agentZhou TJia LLuo YFXu JChen RHGe ZJMa TLChen HZhu TFDove Medical Pressarticlehalloysite nanotubelanthanide complexiron oxideluminescencecontrast agentMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 4765-4776 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	halloysite nanotube lanthanide complex iron oxide luminescence contrast agent Medicine (General) R5-920
spellingShingle	halloysite nanotube lanthanide complex iron oxide luminescence contrast agent Medicine (General) R5-920 Zhou T Jia L Luo YF Xu J Chen RH Ge ZJ Ma TL Chen H Zhu TF Multifunctional nanocomposite based on halloysite nanotubes for efficient luminescent bioimaging and magnetic resonance imaging
description	Tao Zhou,1 Lei Jia,1 Yi-Feng Luo,2 Jun Xu,1 Ru-Hua Chen,2 Zhi-Jun Ge,2 Tie-Liang Ma,2 Hong Chen,2 Tao-Feng Zhu2 1Department of Physics and Chemistry, Henan Polytechnic University, Jiaozuo, Henan, 2The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, People’s Republic of China Abstract: A novel multifunctional halloysite nanotube (HNT)-based Fe3O4@HNT-polyethyleneimine-Tip-Eu(dibenzoylmethane)3 nanocomposite (Fe-HNT-Eu NC) with both photoluminescent and magnetic properties was fabricated by a simple one-step hydrothermal process combined with the coupling grafting method, which exhibited high suspension stability and excellent photophysical behavior. The as-prepared multifunctional Fe-HNT-Eu NC was characterized using various techniques. The results of cell viability assay, cell morphological observation, and in vivo toxicity assay indicated that the NC exhibited excellent biocompatibility over the studied concentration range, suggesting that the obtained Fe-HNT-Eu NC was a suitable material for bioimaging and biological applications in human hepatic adenocarcinoma cells. Furthermore, the biocompatible Fe-HNT-Eu NC displayed superparamagnetic behavior with high saturation magnetization and also functioned as a magnetic resonance imaging (MRI) contrast agent in vitro and in vivo. The results of the MRI tests indicated that the Fe-HNT-Eu NC can significantly decrease the T2 signal intensity values of the normal liver tissue and thus make the boundary between the normal liver and transplanted cancer more distinct, thus effectively improving the diagnosis effect of cancers. Keywords: halloysite nanotube, lanthanide complex, iron oxide, luminescence, contrast agent
format	article
author	Zhou T Jia L Luo YF Xu J Chen RH Ge ZJ Ma TL Chen H Zhu TF
author_facet	Zhou T Jia L Luo YF Xu J Chen RH Ge ZJ Ma TL Chen H Zhu TF
author_sort	Zhou T
title	Multifunctional nanocomposite based on halloysite nanotubes for efficient luminescent bioimaging and magnetic resonance imaging
title_short	Multifunctional nanocomposite based on halloysite nanotubes for efficient luminescent bioimaging and magnetic resonance imaging
title_full	Multifunctional nanocomposite based on halloysite nanotubes for efficient luminescent bioimaging and magnetic resonance imaging
title_fullStr	Multifunctional nanocomposite based on halloysite nanotubes for efficient luminescent bioimaging and magnetic resonance imaging
title_full_unstemmed	Multifunctional nanocomposite based on halloysite nanotubes for efficient luminescent bioimaging and magnetic resonance imaging
title_sort	multifunctional nanocomposite based on halloysite nanotubes for efficient luminescent bioimaging and magnetic resonance imaging
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/d6e6e3ea301249d0b43f52aafb305718
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Multifunctional nanocomposite based on halloysite nanotubes for efficient luminescent bioimaging and magnetic resonance imaging

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