Case-control study of hypertension and Parkinson’s disease

Abstract We evaluate the association of hypertension with PD in an Asian population and performed a meta-analysis on similar studies to address the effect of hypertension on PD risk. A matched case-control study involving 1342 Chinese subjects (671 PD and 671 age and gender-matched controls (with a...

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Autores principales:	Yuen-Fann Ng, Ebonne Ng, Ee-Wei Lim, Kumar M. Prakash, Louis C. S. Tan, Eng-King Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d6e82d5835eb4010bfc8d084d9897612
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spelling	oai:doaj.org-article:d6e82d5835eb4010bfc8d084d98976122021-12-02T16:26:31ZCase-control study of hypertension and Parkinson’s disease10.1038/s41531-021-00202-w2373-8057https://doaj.org/article/d6e82d5835eb4010bfc8d084d98976122021-07-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00202-whttps://doaj.org/toc/2373-8057Abstract We evaluate the association of hypertension with PD in an Asian population and performed a meta-analysis on similar studies to address the effect of hypertension on PD risk. A matched case-control study involving 1342 Chinese subjects (671 PD and 671 age and gender-matched controls (with a mean age of 63.9 ± 9.7 and 63.5 ± 9.8 years, and identical proportion of gender distribution) was conducted. Hypertension increases PD risk by 1.9 times [OR 1.86 (1.46–2.38)]. The literature search identified 618 studies initially; however, only three matched case-control studies (all in Caucasians) met the inclusion criteria for meta-analysis. Overall analysis showed that hypertension decreases PD risk by 0.2 times [OR 0.80 (0.66–0.96)]. Hypertension increases PD risk by 1.9 times in our Asian population. However, a meta-analysis comprising of Caucasian populations showed a protective effect of hypertension suggesting that ethnic differences or other genetic or environmental factors may contribute to the divergent observation. Early diagnosis and treatment of hypertension may potentially reduce the risk of PD, at least in our population.Yuen-Fann NgEbonne NgEe-Wei LimKumar M. PrakashLouis C. S. TanEng-King TanNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Yuen-Fann Ng Ebonne Ng Ee-Wei Lim Kumar M. Prakash Louis C. S. Tan Eng-King Tan Case-control study of hypertension and Parkinson’s disease
description	Abstract We evaluate the association of hypertension with PD in an Asian population and performed a meta-analysis on similar studies to address the effect of hypertension on PD risk. A matched case-control study involving 1342 Chinese subjects (671 PD and 671 age and gender-matched controls (with a mean age of 63.9 ± 9.7 and 63.5 ± 9.8 years, and identical proportion of gender distribution) was conducted. Hypertension increases PD risk by 1.9 times [OR 1.86 (1.46–2.38)]. The literature search identified 618 studies initially; however, only three matched case-control studies (all in Caucasians) met the inclusion criteria for meta-analysis. Overall analysis showed that hypertension decreases PD risk by 0.2 times [OR 0.80 (0.66–0.96)]. Hypertension increases PD risk by 1.9 times in our Asian population. However, a meta-analysis comprising of Caucasian populations showed a protective effect of hypertension suggesting that ethnic differences or other genetic or environmental factors may contribute to the divergent observation. Early diagnosis and treatment of hypertension may potentially reduce the risk of PD, at least in our population.
format	article
author	Yuen-Fann Ng Ebonne Ng Ee-Wei Lim Kumar M. Prakash Louis C. S. Tan Eng-King Tan
author_facet	Yuen-Fann Ng Ebonne Ng Ee-Wei Lim Kumar M. Prakash Louis C. S. Tan Eng-King Tan
author_sort	Yuen-Fann Ng
title	Case-control study of hypertension and Parkinson’s disease
title_short	Case-control study of hypertension and Parkinson’s disease
title_full	Case-control study of hypertension and Parkinson’s disease
title_fullStr	Case-control study of hypertension and Parkinson’s disease
title_full_unstemmed	Case-control study of hypertension and Parkinson’s disease
title_sort	case-control study of hypertension and parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d6e82d5835eb4010bfc8d084d9897612
work_keys_str_mv	AT yuenfannng casecontrolstudyofhypertensionandparkinsonsdisease AT ebonneng casecontrolstudyofhypertensionandparkinsonsdisease AT eeweilim casecontrolstudyofhypertensionandparkinsonsdisease AT kumarmprakash casecontrolstudyofhypertensionandparkinsonsdisease AT louiscstan casecontrolstudyofhypertensionandparkinsonsdisease AT engkingtan casecontrolstudyofhypertensionandparkinsonsdisease
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Case-control study of hypertension and Parkinson’s disease

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