Levosimendan in Europe and China: An Appraisal of Evidence and Context

The calcium sensitiser levosimendan (SIMDAX; Orion Pharma) has been in clinical use for the management of acute heart failure and a range of related syndromes in many countries around the world for two decades. More recently, levosimendan has become available in China. The authors have examined the...

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Autores principales: Xiangqing Kong, Xinqun Hu, Baotong Hua, Francesco Fedele, Dimitrios Farmakis, Piero Pollesello
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Lenguaje:EN
Publicado: Radcliffe Medical Media 2021
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Acceso en línea:https://doaj.org/article/d6ea5947bafb402f8d01baee6e6bf6a7
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spelling oai:doaj.org-article:d6ea5947bafb402f8d01baee6e6bf6a72021-12-04T16:05:18ZLevosimendan in Europe and China: An Appraisal of Evidence and Context10.15420/ecr.2021.411758-37641758-3756https://doaj.org/article/d6ea5947bafb402f8d01baee6e6bf6a72021-11-01T00:00:00Zhttps://www.ecrjournal.com/articleindex/ecr.2021.41https://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764The calcium sensitiser levosimendan (SIMDAX; Orion Pharma) has been in clinical use for the management of acute heart failure and a range of related syndromes in many countries around the world for two decades. More recently, levosimendan has become available in China. The authors have examined the profile of levosimendan in clinical trials conducted inside and outside China and grouped the findings under six headings: effects on haemodynamics, effects on natriuretic peptides, effect on symptoms of heart failure, renal effects, effect on survival, and safety profile. Their conclusions are that under each of these headings there are reasonable grounds to expect that the effects and clinical benefits established in trials and with wider clinical use in Europe and elsewhere will accrue also to Chinese patients. Therefore, the authors are confident that global experience with levosimendan provides a reliable guide to its optimal use and likely therapeutic effects in patients in China.Xiangqing KongXinqun HuBaotong HuaFrancesco FedeleDimitrios FarmakisPiero PolleselloRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 16, Iss , Pp - (2021)
institution DOAJ
collection DOAJ
language EN
topic Diseases of the circulatory (Cardiovascular) system
RC666-701
spellingShingle Diseases of the circulatory (Cardiovascular) system
RC666-701
Xiangqing Kong
Xinqun Hu
Baotong Hua
Francesco Fedele
Dimitrios Farmakis
Piero Pollesello
Levosimendan in Europe and China: An Appraisal of Evidence and Context
description The calcium sensitiser levosimendan (SIMDAX; Orion Pharma) has been in clinical use for the management of acute heart failure and a range of related syndromes in many countries around the world for two decades. More recently, levosimendan has become available in China. The authors have examined the profile of levosimendan in clinical trials conducted inside and outside China and grouped the findings under six headings: effects on haemodynamics, effects on natriuretic peptides, effect on symptoms of heart failure, renal effects, effect on survival, and safety profile. Their conclusions are that under each of these headings there are reasonable grounds to expect that the effects and clinical benefits established in trials and with wider clinical use in Europe and elsewhere will accrue also to Chinese patients. Therefore, the authors are confident that global experience with levosimendan provides a reliable guide to its optimal use and likely therapeutic effects in patients in China.
format article
author Xiangqing Kong
Xinqun Hu
Baotong Hua
Francesco Fedele
Dimitrios Farmakis
Piero Pollesello
author_facet Xiangqing Kong
Xinqun Hu
Baotong Hua
Francesco Fedele
Dimitrios Farmakis
Piero Pollesello
author_sort Xiangqing Kong
title Levosimendan in Europe and China: An Appraisal of Evidence and Context
title_short Levosimendan in Europe and China: An Appraisal of Evidence and Context
title_full Levosimendan in Europe and China: An Appraisal of Evidence and Context
title_fullStr Levosimendan in Europe and China: An Appraisal of Evidence and Context
title_full_unstemmed Levosimendan in Europe and China: An Appraisal of Evidence and Context
title_sort levosimendan in europe and china: an appraisal of evidence and context
publisher Radcliffe Medical Media
publishDate 2021
url https://doaj.org/article/d6ea5947bafb402f8d01baee6e6bf6a7
work_keys_str_mv AT xiangqingkong levosimendanineuropeandchinaanappraisalofevidenceandcontext
AT xinqunhu levosimendanineuropeandchinaanappraisalofevidenceandcontext
AT baotonghua levosimendanineuropeandchinaanappraisalofevidenceandcontext
AT francescofedele levosimendanineuropeandchinaanappraisalofevidenceandcontext
AT dimitriosfarmakis levosimendanineuropeandchinaanappraisalofevidenceandcontext
AT pieropollesello levosimendanineuropeandchinaanappraisalofevidenceandcontext
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