Localization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus

Abstract The circadian pacemaker in the suprachiasmatic nucleus (SCN) yields photoperiodic response to transfer seasonal information to physiology and behavior. To identify the precise location involved in photoperiodic response in the SCN, we analyzed circadian Period1 and PERIOD2 rhythms in horizo...

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Autores principales:	Tomoko Yoshikawa, Natsuko F. Inagaki, Seiji Takagi, Shigeru Kuroda, Miwako Yamasaki, Masahiko Watanabe, Sato Honma, Ken-ichi Honma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d6eb6c9b7d2d4b1b94f1ab7f6c5bee7a
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spelling	oai:doaj.org-article:d6eb6c9b7d2d4b1b94f1ab7f6c5bee7a2021-12-02T11:52:33ZLocalization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus10.1038/s41598-017-08186-52045-2322https://doaj.org/article/d6eb6c9b7d2d4b1b94f1ab7f6c5bee7a2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08186-5https://doaj.org/toc/2045-2322Abstract The circadian pacemaker in the suprachiasmatic nucleus (SCN) yields photoperiodic response to transfer seasonal information to physiology and behavior. To identify the precise location involved in photoperiodic response in the SCN, we analyzed circadian Period1 and PERIOD2 rhythms in horizontally sectioned SCN of mice exposed to a long or short day. Statistical analyses of bioluminescence images with respective luciferase reporters on pixel level enabled us to identify the distinct localization of three oscillating regions; a large open-ring-shape region, the region at the posterior end and a sharply demarcated oval region at the center of the SCN. The first two regions are the respective sites for the so-called evening and morning oscillators, and the third region is possibly a site for mediating photic signals to the former oscillators. In these regions, there are two classes of oscillating cells in which Per1 and Per2 could play differential roles in photoperiodic responses.Tomoko YoshikawaNatsuko F. InagakiSeiji TakagiShigeru KurodaMiwako YamasakiMasahiko WatanabeSato HonmaKen-ichi HonmaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomoko Yoshikawa Natsuko F. Inagaki Seiji Takagi Shigeru Kuroda Miwako Yamasaki Masahiko Watanabe Sato Honma Ken-ichi Honma Localization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus
description	Abstract The circadian pacemaker in the suprachiasmatic nucleus (SCN) yields photoperiodic response to transfer seasonal information to physiology and behavior. To identify the precise location involved in photoperiodic response in the SCN, we analyzed circadian Period1 and PERIOD2 rhythms in horizontally sectioned SCN of mice exposed to a long or short day. Statistical analyses of bioluminescence images with respective luciferase reporters on pixel level enabled us to identify the distinct localization of three oscillating regions; a large open-ring-shape region, the region at the posterior end and a sharply demarcated oval region at the center of the SCN. The first two regions are the respective sites for the so-called evening and morning oscillators, and the third region is possibly a site for mediating photic signals to the former oscillators. In these regions, there are two classes of oscillating cells in which Per1 and Per2 could play differential roles in photoperiodic responses.
format	article
author	Tomoko Yoshikawa Natsuko F. Inagaki Seiji Takagi Shigeru Kuroda Miwako Yamasaki Masahiko Watanabe Sato Honma Ken-ichi Honma
author_facet	Tomoko Yoshikawa Natsuko F. Inagaki Seiji Takagi Shigeru Kuroda Miwako Yamasaki Masahiko Watanabe Sato Honma Ken-ichi Honma
author_sort	Tomoko Yoshikawa
title	Localization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus
title_short	Localization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus
title_full	Localization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus
title_fullStr	Localization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus
title_full_unstemmed	Localization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus
title_sort	localization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d6eb6c9b7d2d4b1b94f1ab7f6c5bee7a
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Localization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus

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