Several frailty parameters highly prevalent in middle age (50–65) are independent predictors of adverse events

Abstract Although frailty can arise in middle age, very few studies have investigated frailty before 65 years. Our objectives were to assess the prevalence of frailty parameters in middle-aged individuals and probe the association with future adverse events. We performed cross-sectional and longitud...

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Autores principales:	Lauriane Segaux, Amaury Broussier, Nadia Oubaya, Claire Leissing-Desprez, Marie Laurent, Henri Naga, Isabelle Fromentin, Jean-Philippe David, Sylvie Bastuji-Garin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d6ed71cda1264ef395ffbef9e3762041
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spelling	oai:doaj.org-article:d6ed71cda1264ef395ffbef9e37620412021-12-02T16:45:15ZSeveral frailty parameters highly prevalent in middle age (50–65) are independent predictors of adverse events10.1038/s41598-021-88410-52045-2322https://doaj.org/article/d6ed71cda1264ef395ffbef9e37620412021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88410-5https://doaj.org/toc/2045-2322Abstract Although frailty can arise in middle age, very few studies have investigated frailty before 65 years. Our objectives were to assess the prevalence of frailty parameters in middle-aged individuals and probe the association with future adverse events. We performed cross-sectional and longitudinal analyses of community-dwelling individuals aged 50 to 65 (n = 411, median age: 59.0) having undergone a multidomain geriatric assessment (2010–2015) in an outpatient clinic in the greater Paris area of France (SUCCEED cohort). The primary outcome was a composite measure of adverse events (non-accidental falls, fractures, unplanned hospitalizations, death), recorded in 2016/2017. Multivariable logistic regression models were built to identify independent predictors. Six frailty parameters were highly prevalent (> 20%): low activity (40.1%), exhaustion (31.3%), living alone (28.5%), balance impairment (26.8%), weakness (26.7%), and executive dysfunction (23.2%). Female sex (odds ratio: 2.67 [95% confidence interval: 1.17–6.11]), living alone (2.39 [1.32–4.33]), balance impairment (2.09 [1.16–3.78]), executive dysfunction (2.61, [1.18–5.77]), and exhaustion (2.98 [1.65–5.39]) were independent predictors of adverse events. Many frailty parameters are already altered in middle-aged individuals and are predictive of adverse health events. Our findings highlight a possible need for frailty screening and preventive programs targeting middle-aged individuals.Lauriane SegauxAmaury BroussierNadia OubayaClaire Leissing-DesprezMarie LaurentHenri NagaIsabelle FromentinJean-Philippe DavidSylvie Bastuji-GarinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lauriane Segaux Amaury Broussier Nadia Oubaya Claire Leissing-Desprez Marie Laurent Henri Naga Isabelle Fromentin Jean-Philippe David Sylvie Bastuji-Garin Several frailty parameters highly prevalent in middle age (50–65) are independent predictors of adverse events
description	Abstract Although frailty can arise in middle age, very few studies have investigated frailty before 65 years. Our objectives were to assess the prevalence of frailty parameters in middle-aged individuals and probe the association with future adverse events. We performed cross-sectional and longitudinal analyses of community-dwelling individuals aged 50 to 65 (n = 411, median age: 59.0) having undergone a multidomain geriatric assessment (2010–2015) in an outpatient clinic in the greater Paris area of France (SUCCEED cohort). The primary outcome was a composite measure of adverse events (non-accidental falls, fractures, unplanned hospitalizations, death), recorded in 2016/2017. Multivariable logistic regression models were built to identify independent predictors. Six frailty parameters were highly prevalent (> 20%): low activity (40.1%), exhaustion (31.3%), living alone (28.5%), balance impairment (26.8%), weakness (26.7%), and executive dysfunction (23.2%). Female sex (odds ratio: 2.67 [95% confidence interval: 1.17–6.11]), living alone (2.39 [1.32–4.33]), balance impairment (2.09 [1.16–3.78]), executive dysfunction (2.61, [1.18–5.77]), and exhaustion (2.98 [1.65–5.39]) were independent predictors of adverse events. Many frailty parameters are already altered in middle-aged individuals and are predictive of adverse health events. Our findings highlight a possible need for frailty screening and preventive programs targeting middle-aged individuals.
format	article
author	Lauriane Segaux Amaury Broussier Nadia Oubaya Claire Leissing-Desprez Marie Laurent Henri Naga Isabelle Fromentin Jean-Philippe David Sylvie Bastuji-Garin
author_facet	Lauriane Segaux Amaury Broussier Nadia Oubaya Claire Leissing-Desprez Marie Laurent Henri Naga Isabelle Fromentin Jean-Philippe David Sylvie Bastuji-Garin
author_sort	Lauriane Segaux
title	Several frailty parameters highly prevalent in middle age (50–65) are independent predictors of adverse events
title_short	Several frailty parameters highly prevalent in middle age (50–65) are independent predictors of adverse events
title_full	Several frailty parameters highly prevalent in middle age (50–65) are independent predictors of adverse events
title_fullStr	Several frailty parameters highly prevalent in middle age (50–65) are independent predictors of adverse events
title_full_unstemmed	Several frailty parameters highly prevalent in middle age (50–65) are independent predictors of adverse events
title_sort	several frailty parameters highly prevalent in middle age (50–65) are independent predictors of adverse events
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d6ed71cda1264ef395ffbef9e3762041
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Several frailty parameters highly prevalent in middle age (50–65) are independent predictors of adverse events

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