NAD+/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro

Yuan et al. characterise metabolic profiles of human mesenchymal stem cells (hMSCs) during cell expansion in culture. They find that late passage hMSCs exhibit a NAD + /NADH redox cycle imbalance and that adding NAD + precursor nicotinamide restores mitochondrial fitness and cellular homeostasis in...

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Autores principales:	Xuegang Yuan, Yijun Liu, Brent M. Bijonowski, Ang-Chen Tsai, Qin Fu, Timothy M. Logan, Teng Ma, Yan Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d6ede884d1f14ddf888a9033545f13b4
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spelling	oai:doaj.org-article:d6ede884d1f14ddf888a9033545f13b42021-12-02T13:56:16ZNAD+/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro10.1038/s42003-020-01514-y2399-3642https://doaj.org/article/d6ede884d1f14ddf888a9033545f13b42020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01514-yhttps://doaj.org/toc/2399-3642Yuan et al. characterise metabolic profiles of human mesenchymal stem cells (hMSCs) during cell expansion in culture. They find that late passage hMSCs exhibit a NAD + /NADH redox cycle imbalance and that adding NAD + precursor nicotinamide restores mitochondrial fitness and cellular homeostasis in senescent hMSCs indicating a possible route to preserve hMSC homeostasis for therapeutic use.Xuegang YuanYijun LiuBrent M. BijonowskiAng-Chen TsaiQin FuTimothy M. LoganTeng MaYan LiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Xuegang Yuan Yijun Liu Brent M. Bijonowski Ang-Chen Tsai Qin Fu Timothy M. Logan Teng Ma Yan Li NAD+/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro
description	Yuan et al. characterise metabolic profiles of human mesenchymal stem cells (hMSCs) during cell expansion in culture. They find that late passage hMSCs exhibit a NAD + /NADH redox cycle imbalance and that adding NAD + precursor nicotinamide restores mitochondrial fitness and cellular homeostasis in senescent hMSCs indicating a possible route to preserve hMSC homeostasis for therapeutic use.
format	article
author	Xuegang Yuan Yijun Liu Brent M. Bijonowski Ang-Chen Tsai Qin Fu Timothy M. Logan Teng Ma Yan Li
author_facet	Xuegang Yuan Yijun Liu Brent M. Bijonowski Ang-Chen Tsai Qin Fu Timothy M. Logan Teng Ma Yan Li
author_sort	Xuegang Yuan
title	NAD+/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro
title_short	NAD+/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro
title_full	NAD+/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro
title_fullStr	NAD+/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro
title_full_unstemmed	NAD+/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro
title_sort	nad+/nadh redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d6ede884d1f14ddf888a9033545f13b4
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NAD+/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro

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