Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDS

Abstract Background Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by lung inflammation and pulmonary edema. Coronavirus disease 2019 (COVID-19) is associated with ARDS in the more severe cases. This study aimed to compare the specificity of the metabolic a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jose Angel Lorente, Nicolas Nin, Palmira Villa, Dovami Vasco, Ana B. Miguel-Coello, Ignacio Rodriguez, Raquel Herrero, Oscar Peñuelas, Jesús Ruiz-Cabello, Jose L. Izquierdo-Garcia
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	ARDS COVID-19 H1N1 influenza Metabolomics NMR Diagnosis Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Acceso en línea:	https://doaj.org/article/d6eef2591bc247b29c05ac488662bac9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d6eef2591bc247b29c05ac488662bac9
record_format	dspace
spelling	oai:doaj.org-article:d6eef2591bc247b29c05ac488662bac92021-11-21T12:02:46ZMetabolomic diferences between COVID-19 and H1N1 influenza induced ARDS10.1186/s13054-021-03810-31364-8535https://doaj.org/article/d6eef2591bc247b29c05ac488662bac92021-11-01T00:00:00Zhttps://doi.org/10.1186/s13054-021-03810-3https://doaj.org/toc/1364-8535Abstract Background Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by lung inflammation and pulmonary edema. Coronavirus disease 2019 (COVID-19) is associated with ARDS in the more severe cases. This study aimed to compare the specificity of the metabolic alterations induced by COVID-19 or Influenza A pneumonia (IAP) in ARDS. Methods Eighteen patients with ARDS due to COVID-19 and twenty patients with ARDS due to IAP, admitted to the intensive care unit. ARDS was defined as in the American-European Consensus Conference. As compared with patients with COVID-19, patients with IAP were younger and received more often noradrenaline to maintain a mean arterial pressure > 65 mm Hg. Serum samples were analyzed by Nuclear Magnetic Resonance Spectroscopy. Multivariate Statistical Analyses were used to identify metabolic differences between groups. Metabolic pathway analysis was performed to identify the most relevant pathways involved in ARDS development. Results ARDS due to COVID-19 or to IAP induces a different regulation of amino acids metabolism, lipid metabolism, glycolysis, and anaplerotic metabolism. COVID‐19 causes a significant energy supply deficit that induces supplementary energy-generating pathways. In contrast, IAP patients suffer more marked inflammatory and oxidative stress responses. The classificatory model discriminated against the cause of pneumonia with a success rate of 100%. Conclusions Our findings support the concept that ARDS is associated with a characteristic metabolomic profile that may discriminate patients with ARDS of different etiologies, being a potential biomarker for the diagnosis, prognosis, and management of this condition. Graphical AbstractJose Angel LorenteNicolas NinPalmira VillaDovami VascoAna B. Miguel-CoelloIgnacio RodriguezRaquel HerreroOscar PeñuelasJesús Ruiz-CabelloJose L. Izquierdo-GarciaBMCarticleARDSCOVID-19H1N1 influenzaMetabolomicsNMRDiagnosisMedical emergencies. Critical care. Intensive care. First aidRC86-88.9ENCritical Care, Vol 25, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ARDS COVID-19 H1N1 influenza Metabolomics NMR Diagnosis Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
spellingShingle	ARDS COVID-19 H1N1 influenza Metabolomics NMR Diagnosis Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 Jose Angel Lorente Nicolas Nin Palmira Villa Dovami Vasco Ana B. Miguel-Coello Ignacio Rodriguez Raquel Herrero Oscar Peñuelas Jesús Ruiz-Cabello Jose L. Izquierdo-Garcia Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDS
description	Abstract Background Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by lung inflammation and pulmonary edema. Coronavirus disease 2019 (COVID-19) is associated with ARDS in the more severe cases. This study aimed to compare the specificity of the metabolic alterations induced by COVID-19 or Influenza A pneumonia (IAP) in ARDS. Methods Eighteen patients with ARDS due to COVID-19 and twenty patients with ARDS due to IAP, admitted to the intensive care unit. ARDS was defined as in the American-European Consensus Conference. As compared with patients with COVID-19, patients with IAP were younger and received more often noradrenaline to maintain a mean arterial pressure > 65 mm Hg. Serum samples were analyzed by Nuclear Magnetic Resonance Spectroscopy. Multivariate Statistical Analyses were used to identify metabolic differences between groups. Metabolic pathway analysis was performed to identify the most relevant pathways involved in ARDS development. Results ARDS due to COVID-19 or to IAP induces a different regulation of amino acids metabolism, lipid metabolism, glycolysis, and anaplerotic metabolism. COVID‐19 causes a significant energy supply deficit that induces supplementary energy-generating pathways. In contrast, IAP patients suffer more marked inflammatory and oxidative stress responses. The classificatory model discriminated against the cause of pneumonia with a success rate of 100%. Conclusions Our findings support the concept that ARDS is associated with a characteristic metabolomic profile that may discriminate patients with ARDS of different etiologies, being a potential biomarker for the diagnosis, prognosis, and management of this condition. Graphical Abstract
format	article
author	Jose Angel Lorente Nicolas Nin Palmira Villa Dovami Vasco Ana B. Miguel-Coello Ignacio Rodriguez Raquel Herrero Oscar Peñuelas Jesús Ruiz-Cabello Jose L. Izquierdo-Garcia
author_facet	Jose Angel Lorente Nicolas Nin Palmira Villa Dovami Vasco Ana B. Miguel-Coello Ignacio Rodriguez Raquel Herrero Oscar Peñuelas Jesús Ruiz-Cabello Jose L. Izquierdo-Garcia
author_sort	Jose Angel Lorente
title	Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDS
title_short	Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDS
title_full	Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDS
title_fullStr	Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDS
title_full_unstemmed	Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDS
title_sort	metabolomic diferences between covid-19 and h1n1 influenza induced ards
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d6eef2591bc247b29c05ac488662bac9
work_keys_str_mv	AT joseangellorente metabolomicdiferencesbetweencovid19andh1n1influenzainducedards AT nicolasnin metabolomicdiferencesbetweencovid19andh1n1influenzainducedards AT palmiravilla metabolomicdiferencesbetweencovid19andh1n1influenzainducedards AT dovamivasco metabolomicdiferencesbetweencovid19andh1n1influenzainducedards AT anabmiguelcoello metabolomicdiferencesbetweencovid19andh1n1influenzainducedards AT ignaciorodriguez metabolomicdiferencesbetweencovid19andh1n1influenzainducedards AT raquelherrero metabolomicdiferencesbetweencovid19andh1n1influenzainducedards AT oscarpenuelas metabolomicdiferencesbetweencovid19andh1n1influenzainducedards AT jesusruizcabello metabolomicdiferencesbetweencovid19andh1n1influenzainducedards AT joselizquierdogarcia metabolomicdiferencesbetweencovid19andh1n1influenzainducedards
_version_	1718419333893324800

Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDS

Ejemplares similares