RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency

RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency

CRISPR/Cas9 and transcription activator-like effector nuclease (TALEN) are becoming major tools for genome editing. Here, Song et al. show that RS-1, a small-molecule enhancer for homology directed repair, increases the CRISPR/Cas9 and TALEN mediated knock-in efficiency both in vitro and in vivowith...

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Autores principales: Jun Song, Dongshan Yang, Jie Xu, Tianqing Zhu, Y. Eugene Chen, Jifeng Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/d6efebaa823c44f48eb43030f42f9f93
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spelling oai:doaj.org-article:d6efebaa823c44f48eb43030f42f9f932021-12-02T15:34:57ZRS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency10.1038/ncomms105482041-1723https://doaj.org/article/d6efebaa823c44f48eb43030f42f9f932016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10548https://doaj.org/toc/2041-1723CRISPR/Cas9 and transcription activator-like effector nuclease (TALEN) are becoming major tools for genome editing. Here, Song et al. show that RS-1, a small-molecule enhancer for homology directed repair, increases the CRISPR/Cas9 and TALEN mediated knock-in efficiency both in vitro and in vivowith rabbit.Jun SongDongshan YangJie XuTianqing ZhuY. Eugene ChenJifeng ZhangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jun Song
Dongshan Yang
Jie Xu
Tianqing Zhu
Y. Eugene Chen
Jifeng Zhang
RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency
description CRISPR/Cas9 and transcription activator-like effector nuclease (TALEN) are becoming major tools for genome editing. Here, Song et al. show that RS-1, a small-molecule enhancer for homology directed repair, increases the CRISPR/Cas9 and TALEN mediated knock-in efficiency both in vitro and in vivowith rabbit.
format article
author Jun Song
Dongshan Yang
Jie Xu
Tianqing Zhu
Y. Eugene Chen
Jifeng Zhang
author_facet Jun Song
Dongshan Yang
Jie Xu
Tianqing Zhu
Y. Eugene Chen
Jifeng Zhang
author_sort Jun Song
title RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency
title_short RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency
title_full RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency
title_fullStr RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency
title_full_unstemmed RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency
title_sort rs-1 enhances crispr/cas9- and talen-mediated knock-in efficiency
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/d6efebaa823c44f48eb43030f42f9f93
work_keys_str_mv AT junsong rs1enhancescrisprcas9andtalenmediatedknockinefficiency
AT dongshanyang rs1enhancescrisprcas9andtalenmediatedknockinefficiency
AT jiexu rs1enhancescrisprcas9andtalenmediatedknockinefficiency
AT tianqingzhu rs1enhancescrisprcas9andtalenmediatedknockinefficiency
AT yeugenechen rs1enhancescrisprcas9andtalenmediatedknockinefficiency
AT jifengzhang rs1enhancescrisprcas9andtalenmediatedknockinefficiency
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