RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency

RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency

CRISPR/Cas9 and transcription activator-like effector nuclease (TALEN) are becoming major tools for genome editing. Here, Song et al. show that RS-1, a small-molecule enhancer for homology directed repair, increases the CRISPR/Cas9 and TALEN mediated knock-in efficiency both in vitro and in vivowith...

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Autores principales: Jun Song, Dongshan Yang, Jie Xu, Tianqing Zhu, Y. Eugene Chen, Jifeng Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/d6efebaa823c44f48eb43030f42f9f93
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