Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes

Toxoplasma gondii is a parasite that causes zoonotic infections in humans. Here, the authors identify tandem amplification and diversification of secretory pathogenesis determinants in the T. gondiigenome and show that clade-specific inheritance of conserved haploblocks enriched for these determinan...

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Autores principales:	Hernan Lorenzi, Asis Khan, Michael S. Behnke, Sivaranjani Namasivayam, Lakshmipuram S. Swapna, Michalis Hadjithomas, Svetlana Karamycheva, Deborah Pinney, Brian P. Brunk, James W. Ajioka, Daniel Ajzenberg, John C. Boothroyd, Jon P. Boyle, Marie L. Dardé, Maria A. Diaz-Miranda, Jitender P. Dubey, Heather M. Fritz, Solange M. Gennari, Brian D. Gregory, Kami Kim, Jeroen P. J. Saeij, Chunlei Su, Michael W. White, Xing-Quan Zhu, Daniel K. Howe, Benjamin M. Rosenthal, Michael E. Grigg, John Parkinson, Liang Liu, Jessica C. Kissinger, David S. Roos, L. David Sibley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d6f0f5ce233e43bc8b47026b7307e2e5
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spelling	oai:doaj.org-article:d6f0f5ce233e43bc8b47026b7307e2e52021-12-02T14:39:49ZLocal admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes10.1038/ncomms101472041-1723https://doaj.org/article/d6f0f5ce233e43bc8b47026b7307e2e52016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10147https://doaj.org/toc/2041-1723Toxoplasma gondii is a parasite that causes zoonotic infections in humans. Here, the authors identify tandem amplification and diversification of secretory pathogenesis determinants in the T. gondiigenome and show that clade-specific inheritance of conserved haploblocks enriched for these determinants shapes population structure.Hernan LorenziAsis KhanMichael S. BehnkeSivaranjani NamasivayamLakshmipuram S. SwapnaMichalis HadjithomasSvetlana KaramychevaDeborah PinneyBrian P. BrunkJames W. AjiokaDaniel AjzenbergJohn C. BoothroydJon P. BoyleMarie L. DardéMaria A. Diaz-MirandaJitender P. DubeyHeather M. FritzSolange M. GennariBrian D. GregoryKami KimJeroen P. J. SaeijChunlei SuMichael W. WhiteXing-Quan ZhuDaniel K. HoweBenjamin M. RosenthalMichael E. GriggJohn ParkinsonLiang LiuJessica C. KissingerDavid S. RoosL. David SibleyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hernan Lorenzi Asis Khan Michael S. Behnke Sivaranjani Namasivayam Lakshmipuram S. Swapna Michalis Hadjithomas Svetlana Karamycheva Deborah Pinney Brian P. Brunk James W. Ajioka Daniel Ajzenberg John C. Boothroyd Jon P. Boyle Marie L. Dardé Maria A. Diaz-Miranda Jitender P. Dubey Heather M. Fritz Solange M. Gennari Brian D. Gregory Kami Kim Jeroen P. J. Saeij Chunlei Su Michael W. White Xing-Quan Zhu Daniel K. Howe Benjamin M. Rosenthal Michael E. Grigg John Parkinson Liang Liu Jessica C. Kissinger David S. Roos L. David Sibley Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes
description	Toxoplasma gondii is a parasite that causes zoonotic infections in humans. Here, the authors identify tandem amplification and diversification of secretory pathogenesis determinants in the T. gondiigenome and show that clade-specific inheritance of conserved haploblocks enriched for these determinants shapes population structure.
format	article
author	Hernan Lorenzi Asis Khan Michael S. Behnke Sivaranjani Namasivayam Lakshmipuram S. Swapna Michalis Hadjithomas Svetlana Karamycheva Deborah Pinney Brian P. Brunk James W. Ajioka Daniel Ajzenberg John C. Boothroyd Jon P. Boyle Marie L. Dardé Maria A. Diaz-Miranda Jitender P. Dubey Heather M. Fritz Solange M. Gennari Brian D. Gregory Kami Kim Jeroen P. J. Saeij Chunlei Su Michael W. White Xing-Quan Zhu Daniel K. Howe Benjamin M. Rosenthal Michael E. Grigg John Parkinson Liang Liu Jessica C. Kissinger David S. Roos L. David Sibley
author_facet	Hernan Lorenzi Asis Khan Michael S. Behnke Sivaranjani Namasivayam Lakshmipuram S. Swapna Michalis Hadjithomas Svetlana Karamycheva Deborah Pinney Brian P. Brunk James W. Ajioka Daniel Ajzenberg John C. Boothroyd Jon P. Boyle Marie L. Dardé Maria A. Diaz-Miranda Jitender P. Dubey Heather M. Fritz Solange M. Gennari Brian D. Gregory Kami Kim Jeroen P. J. Saeij Chunlei Su Michael W. White Xing-Quan Zhu Daniel K. Howe Benjamin M. Rosenthal Michael E. Grigg John Parkinson Liang Liu Jessica C. Kissinger David S. Roos L. David Sibley
author_sort	Hernan Lorenzi
title	Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes
title_short	Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes
title_full	Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes
title_fullStr	Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes
title_full_unstemmed	Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes
title_sort	local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic toxoplasma gondii genomes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d6f0f5ce233e43bc8b47026b7307e2e5
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Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes

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