The Effect of Bisphenol A on the IVF Outcomes Depending on the Polymorphism of the Detoxification System Genes

The aim of the study was to analyze the relationship between the level of bisphenol A (BPA) in the blood and follicular fluid, the polymorphism of the detoxification system genes, and the outcomes of IVF cycles. The data of 300 infertile patients with fresh IVF-ET cycles were analyzed. The level of...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Anastasiya Syrkasheva, Vladimir Frankevich, Svetlana Kindysheva, Nataliia Starodubtseva, Andrey Donnikov, Nataliya Dolgushina
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
R
Acceso en línea:https://doaj.org/article/d6f3901d58df4763af35c52bd693573d
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:The aim of the study was to analyze the relationship between the level of bisphenol A (BPA) in the blood and follicular fluid, the polymorphism of the detoxification system genes, and the outcomes of IVF cycles. The data of 300 infertile patients with fresh IVF-ET cycles were analyzed. The level of BPA in the blood and follicular fluid was determined by HPLC-MRM-MS/MS. Determination of genotypes of the detoxification system genes was carried out by the real-time PCR. The threshold level for determining BPA was 0.1 ng/mL. BPA was detected in 92.3% (277/300) blood and in 16.8% (49/292) follicular fluid (FF) samples. There was no correlation between BPA level in the blood and FF. In patients with the absence of the A allele of the <i>SULT1A1</i> gene, BPA was detected in FF significantly more often (22.6% vs. 13.5%, <i>p</i> = 0.0341). There was an association (not statistically significant) between the level of BPA in the blood and the presence of the G allele of the <i>GSTP1</i> gene (rs1695) and the C allele in the <i>GSTP1</i> gene (rs1138272). Our data suggests the role of detoxification system genes in the metabolism of BPA in the human body. The influence of BPA and detoxification system genes on the IVF outcomes requires further research.