The Effect of Bisphenol A on the IVF Outcomes Depending on the Polymorphism of the Detoxification System Genes

The aim of the study was to analyze the relationship between the level of bisphenol A (BPA) in the blood and follicular fluid, the polymorphism of the detoxification system genes, and the outcomes of IVF cycles. The data of 300 infertile patients with fresh IVF-ET cycles were analyzed. The level of...

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Autores principales:	Anastasiya Syrkasheva, Vladimir Frankevich, Svetlana Kindysheva, Nataliia Starodubtseva, Andrey Donnikov, Nataliya Dolgushina
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	assisted reproductive technologies embryo pregnancy endocrine disruptors bisphenol A HPLC-MS Medicine R
Acceso en línea:	https://doaj.org/article/d6f3901d58df4763af35c52bd693573d
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spelling	oai:doaj.org-article:d6f3901d58df4763af35c52bd693573d2021-11-25T18:07:04ZThe Effect of Bisphenol A on the IVF Outcomes Depending on the Polymorphism of the Detoxification System Genes10.3390/jpm111110912075-4426https://doaj.org/article/d6f3901d58df4763af35c52bd693573d2021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1091https://doaj.org/toc/2075-4426The aim of the study was to analyze the relationship between the level of bisphenol A (BPA) in the blood and follicular fluid, the polymorphism of the detoxification system genes, and the outcomes of IVF cycles. The data of 300 infertile patients with fresh IVF-ET cycles were analyzed. The level of BPA in the blood and follicular fluid was determined by HPLC-MRM-MS/MS. Determination of genotypes of the detoxification system genes was carried out by the real-time PCR. The threshold level for determining BPA was 0.1 ng/mL. BPA was detected in 92.3% (277/300) blood and in 16.8% (49/292) follicular fluid (FF) samples. There was no correlation between BPA level in the blood and FF. In patients with the absence of the A allele of the <i>SULT1A1</i> gene, BPA was detected in FF significantly more often (22.6% vs. 13.5%, <i>p</i> = 0.0341). There was an association (not statistically significant) between the level of BPA in the blood and the presence of the G allele of the <i>GSTP1</i> gene (rs1695) and the C allele in the <i>GSTP1</i> gene (rs1138272). Our data suggests the role of detoxification system genes in the metabolism of BPA in the human body. The influence of BPA and detoxification system genes on the IVF outcomes requires further research.Anastasiya SyrkashevaVladimir FrankevichSvetlana KindyshevaNataliia StarodubtsevaAndrey DonnikovNataliya DolgushinaMDPI AGarticleassisted reproductive technologiesembryopregnancyendocrine disruptorsbisphenol AHPLC-MSMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1091, p 1091 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	assisted reproductive technologies embryo pregnancy endocrine disruptors bisphenol A HPLC-MS Medicine R
spellingShingle	assisted reproductive technologies embryo pregnancy endocrine disruptors bisphenol A HPLC-MS Medicine R Anastasiya Syrkasheva Vladimir Frankevich Svetlana Kindysheva Nataliia Starodubtseva Andrey Donnikov Nataliya Dolgushina The Effect of Bisphenol A on the IVF Outcomes Depending on the Polymorphism of the Detoxification System Genes
description	The aim of the study was to analyze the relationship between the level of bisphenol A (BPA) in the blood and follicular fluid, the polymorphism of the detoxification system genes, and the outcomes of IVF cycles. The data of 300 infertile patients with fresh IVF-ET cycles were analyzed. The level of BPA in the blood and follicular fluid was determined by HPLC-MRM-MS/MS. Determination of genotypes of the detoxification system genes was carried out by the real-time PCR. The threshold level for determining BPA was 0.1 ng/mL. BPA was detected in 92.3% (277/300) blood and in 16.8% (49/292) follicular fluid (FF) samples. There was no correlation between BPA level in the blood and FF. In patients with the absence of the A allele of the <i>SULT1A1</i> gene, BPA was detected in FF significantly more often (22.6% vs. 13.5%, <i>p</i> = 0.0341). There was an association (not statistically significant) between the level of BPA in the blood and the presence of the G allele of the <i>GSTP1</i> gene (rs1695) and the C allele in the <i>GSTP1</i> gene (rs1138272). Our data suggests the role of detoxification system genes in the metabolism of BPA in the human body. The influence of BPA and detoxification system genes on the IVF outcomes requires further research.
format	article
author	Anastasiya Syrkasheva Vladimir Frankevich Svetlana Kindysheva Nataliia Starodubtseva Andrey Donnikov Nataliya Dolgushina
author_facet	Anastasiya Syrkasheva Vladimir Frankevich Svetlana Kindysheva Nataliia Starodubtseva Andrey Donnikov Nataliya Dolgushina
author_sort	Anastasiya Syrkasheva
title	The Effect of Bisphenol A on the IVF Outcomes Depending on the Polymorphism of the Detoxification System Genes
title_short	The Effect of Bisphenol A on the IVF Outcomes Depending on the Polymorphism of the Detoxification System Genes
title_full	The Effect of Bisphenol A on the IVF Outcomes Depending on the Polymorphism of the Detoxification System Genes
title_fullStr	The Effect of Bisphenol A on the IVF Outcomes Depending on the Polymorphism of the Detoxification System Genes
title_full_unstemmed	The Effect of Bisphenol A on the IVF Outcomes Depending on the Polymorphism of the Detoxification System Genes
title_sort	effect of bisphenol a on the ivf outcomes depending on the polymorphism of the detoxification system genes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d6f3901d58df4763af35c52bd693573d
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The Effect of Bisphenol A on the IVF Outcomes Depending on the Polymorphism of the Detoxification System Genes

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