The Interaction of Natural and Vaccine-Induced Immunity with Social Distancing Predicts the Evolution of the COVID-19 Pandemic

ABSTRACT The existence and nature of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are currently unknown; however, neutralizing antibodies are thought to play the major role and data from studying other coronaviruses suggest that partial clinical immunity lasting up to 1 y...

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Autores principales:	Michael F. Good, Michael T. Hawkes
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	SARS-CoV-2 COVID-19 immunity public health vaccines Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/d6f5f56e0d1544b7926ae0717305fd64
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spelling	oai:doaj.org-article:d6f5f56e0d1544b7926ae0717305fd642021-11-15T16:19:07ZThe Interaction of Natural and Vaccine-Induced Immunity with Social Distancing Predicts the Evolution of the COVID-19 Pandemic10.1128/mBio.02617-202150-7511https://doaj.org/article/d6f5f56e0d1544b7926ae0717305fd642020-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02617-20https://doaj.org/toc/2150-7511ABSTRACT The existence and nature of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are currently unknown; however, neutralizing antibodies are thought to play the major role and data from studying other coronaviruses suggest that partial clinical immunity lasting up to 1 year will occur postinfection. We show how immunity, depending on its durability, may work with current social practices to limit the spread of the virus. We further show that a vaccine that is 50% effective and taken by 50% of the population will prevent further loss of life, providing that social distancing is still practiced and that immunity does not wane quickly. IMPORTANCE The ability of our society to function effectively moving forward will depend on how the spread of the SARS-CoV-2 virus is contained. Immunity to the virus will be critical to this equation.Michael F. GoodMichael T. HawkesAmerican Society for MicrobiologyarticleSARS-CoV-2COVID-19immunitypublic healthvaccinesSARS-CoV-2MicrobiologyQR1-502ENmBio, Vol 11, Iss 5 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 immunity public health vaccines SARS-CoV-2 Microbiology QR1-502
spellingShingle	SARS-CoV-2 COVID-19 immunity public health vaccines SARS-CoV-2 Microbiology QR1-502 Michael F. Good Michael T. Hawkes The Interaction of Natural and Vaccine-Induced Immunity with Social Distancing Predicts the Evolution of the COVID-19 Pandemic
description	ABSTRACT The existence and nature of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are currently unknown; however, neutralizing antibodies are thought to play the major role and data from studying other coronaviruses suggest that partial clinical immunity lasting up to 1 year will occur postinfection. We show how immunity, depending on its durability, may work with current social practices to limit the spread of the virus. We further show that a vaccine that is 50% effective and taken by 50% of the population will prevent further loss of life, providing that social distancing is still practiced and that immunity does not wane quickly. IMPORTANCE The ability of our society to function effectively moving forward will depend on how the spread of the SARS-CoV-2 virus is contained. Immunity to the virus will be critical to this equation.
format	article
author	Michael F. Good Michael T. Hawkes
author_facet	Michael F. Good Michael T. Hawkes
author_sort	Michael F. Good
title	The Interaction of Natural and Vaccine-Induced Immunity with Social Distancing Predicts the Evolution of the COVID-19 Pandemic
title_short	The Interaction of Natural and Vaccine-Induced Immunity with Social Distancing Predicts the Evolution of the COVID-19 Pandemic
title_full	The Interaction of Natural and Vaccine-Induced Immunity with Social Distancing Predicts the Evolution of the COVID-19 Pandemic
title_fullStr	The Interaction of Natural and Vaccine-Induced Immunity with Social Distancing Predicts the Evolution of the COVID-19 Pandemic
title_full_unstemmed	The Interaction of Natural and Vaccine-Induced Immunity with Social Distancing Predicts the Evolution of the COVID-19 Pandemic
title_sort	interaction of natural and vaccine-induced immunity with social distancing predicts the evolution of the covid-19 pandemic
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/d6f5f56e0d1544b7926ae0717305fd64
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The Interaction of Natural and Vaccine-Induced Immunity with Social Distancing Predicts the Evolution of the COVID-19 Pandemic

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