Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination

Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination

Class switch DNA recombination (CSR) is critical for maturation of antibody response, and relies on Ku-mediated NHEJ of DSBs in the IgH S regions for recombination. This study shows Rad52 contributes to CSR through a Ku-independent alternative NHEJ that introduces microhomologies in S–S junctions.

Guardado en:
Detalles Bibliográficos
Autores principales: Hong Zan, Connie Tat, Zhifang Qiu, Julia R. Taylor, Justin A. Guerrero, Tian Shen, Paolo Casali
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/d6f6f6683fe04489b885a9c945d465d8
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:d6f6f6683fe04489b885a9c945d465d8
record_format dspace
spelling oai:doaj.org-article:d6f6f6683fe04489b885a9c945d465d82021-12-02T17:06:12ZRad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination10.1038/ncomms142442041-1723https://doaj.org/article/d6f6f6683fe04489b885a9c945d465d82017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14244https://doaj.org/toc/2041-1723Class switch DNA recombination (CSR) is critical for maturation of antibody response, and relies on Ku-mediated NHEJ of DSBs in the IgH S regions for recombination. This study shows Rad52 contributes to CSR through a Ku-independent alternative NHEJ that introduces microhomologies in S–S junctions.Hong ZanConnie TatZhifang QiuJulia R. TaylorJustin A. GuerreroTian ShenPaolo CasaliNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hong Zan
Connie Tat
Zhifang Qiu
Julia R. Taylor
Justin A. Guerrero
Tian Shen
Paolo Casali
Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
description Class switch DNA recombination (CSR) is critical for maturation of antibody response, and relies on Ku-mediated NHEJ of DSBs in the IgH S regions for recombination. This study shows Rad52 contributes to CSR through a Ku-independent alternative NHEJ that introduces microhomologies in S–S junctions.
format article
author Hong Zan
Connie Tat
Zhifang Qiu
Julia R. Taylor
Justin A. Guerrero
Tian Shen
Paolo Casali
author_facet Hong Zan
Connie Tat
Zhifang Qiu
Julia R. Taylor
Justin A. Guerrero
Tian Shen
Paolo Casali
author_sort Hong Zan
title Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
title_short Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
title_full Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
title_fullStr Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
title_full_unstemmed Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
title_sort rad52 competes with ku70/ku86 for binding to s-region dsb ends to modulate antibody class-switch dna recombination
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/d6f6f6683fe04489b885a9c945d465d8
work_keys_str_mv AT hongzan rad52competeswithku70ku86forbindingtosregiondsbendstomodulateantibodyclassswitchdnarecombination
AT connietat rad52competeswithku70ku86forbindingtosregiondsbendstomodulateantibodyclassswitchdnarecombination
AT zhifangqiu rad52competeswithku70ku86forbindingtosregiondsbendstomodulateantibodyclassswitchdnarecombination
AT juliartaylor rad52competeswithku70ku86forbindingtosregiondsbendstomodulateantibodyclassswitchdnarecombination
AT justinaguerrero rad52competeswithku70ku86forbindingtosregiondsbendstomodulateantibodyclassswitchdnarecombination
AT tianshen rad52competeswithku70ku86forbindingtosregiondsbendstomodulateantibodyclassswitchdnarecombination
AT paolocasali rad52competeswithku70ku86forbindingtosregiondsbendstomodulateantibodyclassswitchdnarecombination
_version_ 1718381702605176832

Ejemplares similares