Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
Class switch DNA recombination (CSR) is critical for maturation of antibody response, and relies on Ku-mediated NHEJ of DSBs in the IgH S regions for recombination. This study shows Rad52 contributes to CSR through a Ku-independent alternative NHEJ that introduces microhomologies in S–S junctions.
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2017
|
| Subjects: | |
| Online Access: | https://doaj.org/article/d6f6f6683fe04489b885a9c945d465d8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|