MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing
Aberrant alternative splicing has been shown to contribute to the tumorigenic processes. Here, the authors show that MTR4 is overexpressed in hepatocellular carcinoma and has a role in tumorigenesis through the modulation of the splicing of glycolytic genes PKM2 and GLUT1.
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Nature Portfolio
2020
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oai:doaj.org-article:d6f7056973d7420fa80b0b12ab8c2f6e2021-12-02T14:40:51ZMTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing10.1038/s41467-020-14437-32041-1723https://doaj.org/article/d6f7056973d7420fa80b0b12ab8c2f6e2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14437-3https://doaj.org/toc/2041-1723Aberrant alternative splicing has been shown to contribute to the tumorigenic processes. Here, the authors show that MTR4 is overexpressed in hepatocellular carcinoma and has a role in tumorigenesis through the modulation of the splicing of glycolytic genes PKM2 and GLUT1.Lili YuJinchul KimLei JiangBingbing FengYue YingKai-yuan JiQingshuang TangWancheng ChenTaoyi MaiWenlong DouJianlong ZhouLe-yang XiangYang-fan HeDinghua YangQingjiao LiXuemei FuYang XuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Lili Yu Jinchul Kim Lei Jiang Bingbing Feng Yue Ying Kai-yuan Ji Qingshuang Tang Wancheng Chen Taoyi Mai Wenlong Dou Jianlong Zhou Le-yang Xiang Yang-fan He Dinghua Yang Qingjiao Li Xuemei Fu Yang Xu MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing |
| description |
Aberrant alternative splicing has been shown to contribute to the tumorigenic processes. Here, the authors show that MTR4 is overexpressed in hepatocellular carcinoma and has a role in tumorigenesis through the modulation of the splicing of glycolytic genes PKM2 and GLUT1. |
| format |
article |
| author |
Lili Yu Jinchul Kim Lei Jiang Bingbing Feng Yue Ying Kai-yuan Ji Qingshuang Tang Wancheng Chen Taoyi Mai Wenlong Dou Jianlong Zhou Le-yang Xiang Yang-fan He Dinghua Yang Qingjiao Li Xuemei Fu Yang Xu |
| author_facet |
Lili Yu Jinchul Kim Lei Jiang Bingbing Feng Yue Ying Kai-yuan Ji Qingshuang Tang Wancheng Chen Taoyi Mai Wenlong Dou Jianlong Zhou Le-yang Xiang Yang-fan He Dinghua Yang Qingjiao Li Xuemei Fu Yang Xu |
| author_sort |
Lili Yu |
| title |
MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing |
| title_short |
MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing |
| title_full |
MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing |
| title_fullStr |
MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing |
| title_full_unstemmed |
MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing |
| title_sort |
mtr4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/d6f7056973d7420fa80b0b12ab8c2f6e |
| work_keys_str_mv |
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