LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β

Several lncRNAs are regulated by TGF-β. Here the authors report that an intergenic lncRNA —EPR— is a component of the TGF-β signaling pathway and controls epithelial cell proliferation by altering transcription and mRNA decay of Cdkn1a. EPR overexpression restrains tumor growth of orthotopically tra...

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Autores principales:	Martina Rossi, Gabriele Bucci, Dario Rizzotto, Domenico Bordo, Matteo J. Marzi, Margherita Puppo, Arielle Flinois, Domenica Spadaro, Sandra Citi, Laura Emionite, Michele Cilli, Francesco Nicassio, Alberto Inga, Paola Briata, Roberto Gherzi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d6f7e15deb314cbf950c9b2234270de8
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spelling	oai:doaj.org-article:d6f7e15deb314cbf950c9b2234270de82021-12-02T14:40:21ZLncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β10.1038/s41467-019-09754-12041-1723https://doaj.org/article/d6f7e15deb314cbf950c9b2234270de82019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09754-1https://doaj.org/toc/2041-1723Several lncRNAs are regulated by TGF-β. Here the authors report that an intergenic lncRNA —EPR— is a component of the TGF-β signaling pathway and controls epithelial cell proliferation by altering transcription and mRNA decay of Cdkn1a. EPR overexpression restrains tumor growth of orthotopically transplanted mice.Martina RossiGabriele BucciDario RizzottoDomenico BordoMatteo J. MarziMargherita PuppoArielle FlinoisDomenica SpadaroSandra CitiLaura EmioniteMichele CilliFrancesco NicassioAlberto IngaPaola BriataRoberto GherziNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martina Rossi Gabriele Bucci Dario Rizzotto Domenico Bordo Matteo J. Marzi Margherita Puppo Arielle Flinois Domenica Spadaro Sandra Citi Laura Emionite Michele Cilli Francesco Nicassio Alberto Inga Paola Briata Roberto Gherzi LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β
description	Several lncRNAs are regulated by TGF-β. Here the authors report that an intergenic lncRNA —EPR— is a component of the TGF-β signaling pathway and controls epithelial cell proliferation by altering transcription and mRNA decay of Cdkn1a. EPR overexpression restrains tumor growth of orthotopically transplanted mice.
format	article
author	Martina Rossi Gabriele Bucci Dario Rizzotto Domenico Bordo Matteo J. Marzi Margherita Puppo Arielle Flinois Domenica Spadaro Sandra Citi Laura Emionite Michele Cilli Francesco Nicassio Alberto Inga Paola Briata Roberto Gherzi
author_facet	Martina Rossi Gabriele Bucci Dario Rizzotto Domenico Bordo Matteo J. Marzi Margherita Puppo Arielle Flinois Domenica Spadaro Sandra Citi Laura Emionite Michele Cilli Francesco Nicassio Alberto Inga Paola Briata Roberto Gherzi
author_sort	Martina Rossi
title	LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β
title_short	LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β
title_full	LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β
title_fullStr	LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β
title_full_unstemmed	LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β
title_sort	lncrna epr controls epithelial proliferation by coordinating cdkn1a transcription and mrna decay response to tgf-β
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d6f7e15deb314cbf950c9b2234270de8
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LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β

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