LimpiAD foam and the potential control of the pressure ulcers onset

Pressure ulcers development is an undesirable event that often worsens the clinical condition of patients already affected by severe pathologies. Since the aetiology of this clinical complication is unclear yet, at current the primary approach to treat the problem is the adoption of suitable patient...

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Autores principales:	Laura Pietrangelo, Irene Magnifico, Antonella Guerrera, Marco Alfio Cutuli, Giulio Petronio Petronio, Noemi Venditti, Matteo Covelli, Nicandro Buccieri, Silvio Garofalo, Roberto Di Marco
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Pressure ulcers Decubitus Bedsores Wounds Skin microbiota C. acnes Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d6fa5de4e6134eb89ba141e157ddbc79
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spelling	oai:doaj.org-article:d6fa5de4e6134eb89ba141e157ddbc792021-11-14T04:29:44ZLimpiAD foam and the potential control of the pressure ulcers onset0753-332210.1016/j.biopha.2021.112327https://doaj.org/article/d6fa5de4e6134eb89ba141e157ddbc792021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011112https://doaj.org/toc/0753-3322Pressure ulcers development is an undesirable event that often worsens the clinical condition of patients already affected by severe pathologies. Since the aetiology of this clinical complication is unclear yet, at current the primary approach to treat the problem is the adoption of suitable patients’ assistance procedures. At the same time, the research focuses on finding medicaments or treatment strategies that could prevent the lesions and/or accelerate their healing. The international market's wide range of cosmetic/pharmaceuticals products is mainly topical preparations based on emollient agents to preserve or restore skin homeostasis. On the other hand, the skin microbiome's implication in the pressure ulcers occurrence is mainly unknown. Based on these assumptions, here we tested an innovative preparation, the LimpiAD foam, as a potential preventive strategy of pressure ulcers onset. The active component of this product is composed of hyaluronic acid conjugated with a bacterial cell wall fragment of C. acnes DSM 28251. For LimpiAD foam, we hypothesised a combined action of the two components on the skin tissue, an emollient effect due to the hyaluronic acid properties together with a modulatory effect on the skin microbiota carried out by the component of bacterial derivation. Our results supported the hypothesis and suggested a potential role of LimpiAD foam in pressure ulcers prevention.Laura PietrangeloIrene MagnificoAntonella GuerreraMarco Alfio CutuliGiulio Petronio PetronioNoemi VendittiMatteo CovelliNicandro BuccieriSilvio GarofaloRoberto Di MarcoElsevierarticlePressure ulcersDecubitusBedsoresWoundsSkin microbiotaC. acnesTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112327- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pressure ulcers Decubitus Bedsores Wounds Skin microbiota C. acnes Therapeutics. Pharmacology RM1-950
spellingShingle	Pressure ulcers Decubitus Bedsores Wounds Skin microbiota C. acnes Therapeutics. Pharmacology RM1-950 Laura Pietrangelo Irene Magnifico Antonella Guerrera Marco Alfio Cutuli Giulio Petronio Petronio Noemi Venditti Matteo Covelli Nicandro Buccieri Silvio Garofalo Roberto Di Marco LimpiAD foam and the potential control of the pressure ulcers onset
description	Pressure ulcers development is an undesirable event that often worsens the clinical condition of patients already affected by severe pathologies. Since the aetiology of this clinical complication is unclear yet, at current the primary approach to treat the problem is the adoption of suitable patients’ assistance procedures. At the same time, the research focuses on finding medicaments or treatment strategies that could prevent the lesions and/or accelerate their healing. The international market's wide range of cosmetic/pharmaceuticals products is mainly topical preparations based on emollient agents to preserve or restore skin homeostasis. On the other hand, the skin microbiome's implication in the pressure ulcers occurrence is mainly unknown. Based on these assumptions, here we tested an innovative preparation, the LimpiAD foam, as a potential preventive strategy of pressure ulcers onset. The active component of this product is composed of hyaluronic acid conjugated with a bacterial cell wall fragment of C. acnes DSM 28251. For LimpiAD foam, we hypothesised a combined action of the two components on the skin tissue, an emollient effect due to the hyaluronic acid properties together with a modulatory effect on the skin microbiota carried out by the component of bacterial derivation. Our results supported the hypothesis and suggested a potential role of LimpiAD foam in pressure ulcers prevention.
format	article
author	Laura Pietrangelo Irene Magnifico Antonella Guerrera Marco Alfio Cutuli Giulio Petronio Petronio Noemi Venditti Matteo Covelli Nicandro Buccieri Silvio Garofalo Roberto Di Marco
author_facet	Laura Pietrangelo Irene Magnifico Antonella Guerrera Marco Alfio Cutuli Giulio Petronio Petronio Noemi Venditti Matteo Covelli Nicandro Buccieri Silvio Garofalo Roberto Di Marco
author_sort	Laura Pietrangelo
title	LimpiAD foam and the potential control of the pressure ulcers onset
title_short	LimpiAD foam and the potential control of the pressure ulcers onset
title_full	LimpiAD foam and the potential control of the pressure ulcers onset
title_fullStr	LimpiAD foam and the potential control of the pressure ulcers onset
title_full_unstemmed	LimpiAD foam and the potential control of the pressure ulcers onset
title_sort	limpiad foam and the potential control of the pressure ulcers onset
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d6fa5de4e6134eb89ba141e157ddbc79
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LimpiAD foam and the potential control of the pressure ulcers onset

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